Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Additional information:

In accordance with REACH Annex VII, column 2 adaptation, studies on skin sensitisation do not need to be conducted as members of the butenes category are flammable gases at room temperature. No studies have been conducted on skin sensitisation with the butenes category but there are no indications from repeat dose studies that any of the butenes cause skin sensitisation.


Migrated from Short description of key information:
There are no data on skin sensitisation and no indications that members of the butenes category are skin sensitizers. The butenes are flammable gases at room temperature and therefore studies on skin sensitisation are waived.

Respiratory sensitisation

Endpoint conclusion
Additional information:

No studies have been conducted on respiratory sensitisation with the members of the butenes category but there is no data to indicate that any of the butenes would cause respiratory sensitisation.


Migrated from Short description of key information:
No studies have been conducted but there no indications that members of the butenes category are respiratory sensitizers.

Justification for classification or non-classification

There is no indication that members of the butenes category cause skin or respiratory sensitisation and therefore, according to the EU and GHS/CLP criteria, the butenes do not require classification for sensitisation properties.