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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
From 12 MAY 1981 to 26 MAY 1981
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Does not meet important criteria of today standard methods (diameter of particulates not determined, insufficient reporting of exposure concentration, no data on test item purity)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report Date:
1981

Materials and methods

Test guidelineopen allclose all
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Qualifier:
according to
Guideline:
other: company guideline similar to OECD guideline 403
Deviations:
no
GLP compliance:
no
Remarks:
GLP was not compulsory at the time the study was conducted
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: particulates

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
nose only
Vehicle:
air
Analytical verification of test atmosphere concentrations:
yes
Remarks:
gravimetric
Duration of exposure:
4 h
Remarks on duration:
14 days observation period
Concentrations:
mean 1580 mg/cubic metre (787-2479)
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- test concentration was the highest technically feasible concentration

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 1 580 mg/m³ air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: no animal died during exposure or post observation period (highest technically feasible concentration)

Any other information on results incl. tables

- animals showed irregular breathing during exposure

- no animal died during exposure or post observation period

- normal body weight development during post observation period

- no macroscopic findings at necropsy

Applicant's summary and conclusion

Conclusions:
The test item was not toxic when administerd to rats via nose-only inhalation at the highest technically feasible concentration of 1580 mg per cubic metre.