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EC number: 224-867-1 | CAS number: 4531-49-1
- no premature deaths in any dose group
- fur stained with test material in all animals treated with the test item
- hunched posture in some animals at 5000 mg/kg bw
- one animal with lethargy at 5000 mg/kg bw
There was no statistically significant increase in the frequency of micronucleated PCE's and in the PCE/NCE ratio in any dose group when compared to the concurrent vehicle control groups.
The positive control goup showed a marked increase in the incidence of micronucleated PCE.
Genetic toxicity of the test item has been investigated in an in vivo micronucleus assay in male and female ICR mice (5 per sex and group). The test item was administered at the maximum recommended dose level of 5000 mg/kg bw, with 2500 and 1250 mg/kg bw as the two lower dose levels. Animals were killed 24, 48 or 72 hours later. Evaluation of polychromatic (PCE) or normochromatic (NCE) erythrocytes did not reveal any evidence of an increase in the incidence of micronucleated cells. No significant change in the PCE/NCE ratio was observed after dosing with the test item, however, clinical signs were observed in animals dosed with the test item and as such are evidence of systemic exposure. The positive control material produced a marked increase in the frequency of micronucleated PCE. The test material was considered to be non-genotoxic under the conditions of the test.
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