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Administrative data

Endpoint:
nanomaterial dustiness
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Remarks:
according to DIN EN 17199-3

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: DIN EN 17199-3
Version / remarks:
measurement of dustiness of bulk materials that contain or release respirable NOAA or other respirable particles - Part 3: Continuous drop method
Deviations:
yes
Remarks:
1 meaurement performed
GLP compliance:
no
Type of method:
continuous drop
Sampling:
The test material was used without further treatment (e.g. drying). 93.3 g (396.3 cm3) test material are used for the measurement, dosing rate: 9.33 g/min

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2-methoxyphenyl)-3-oxobutyramide]
EC Number:
224-867-1
EC Name:
2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2-methoxyphenyl)-3-oxobutyramide]
Cas Number:
4531-49-1
Molecular formula:
C34H30Cl2N6O6
IUPAC Name:
2,2'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[N-(2-methoxyphenyl)-3-oxobutanamide]
Test material form:
solid: nanoform

Results and discussion

Dustiness indexopen allclose all
Key result
Mean:
100 317.6 other: 1/mg
Remarks on result:
other: dustiness index as number of airborne particles per mg in the nanoscale (10 nm - 100 nm)
Mean:
17 659.7 other: N/cm3
Remarks on result:
other: number of airborne nanoparticles per cm3

Any other information on results incl. tables

measurement duration: 10 min

temperature: 30°C, rel. air humidity 55 %

The cleaned, almost particle-free air had a total particle count of 7 particles/cm3 in the range of 10 nm - 417 nm, the nanoscale fraction (10 - 100 nm) contained 4 particles/cm3.

table 1: summary SMPS (sanning mobility particle sizer)

Range [nm]

Mean [nm]

Concentration [N/cm3]

ICD[1/mg]

ECD[1/mg x s]

10 - 100

66.7

17659.7

100317.6

167.2

100 - 417

209.9

59096.8

335705.1

559.5

10 - 417

176.9

76756.4

436022.7

726.7

ICD: dustiness index as number of airborne particles per mg

ECD: emission rate as number of particles per mg per second

mean: average particle diameter in nm

N: number of airborne particles

table 2: summary OPS (optical particle sizer)

Range [µm]

Mean [µm]

Concentration [N/cm3]

ICD[1/mg]

ECD[1/mg x s]

0.3 - 10

4.4

193.8

1101.1

1.8

Applicant's summary and conclusion

Executive summary:

The dusting behaviour of the test material was investigated using DIN EN 17199 -3: 2019 -12 "workplace exposure - measurement of dustiness of bulk materials that contain or release respirable nano objects and their aggregates and agglomerates or other respirable particles- Part 3: Copntinuous drop method".

The dust released by the falling test material was measured by a scanning mobility particle sizer (SMPS, 10 - 417 nm) and an optical particle sizer (3 - 10 µm). The counterflow was provided by cleaned, almost particle-free air.

The SMPS counted 76756.4 particles per cm3 (in the nanoscale (10 - 100 m) 17659.7 particles per cm3) corresponding to a dustiness index of 436022.7 particles per mg (in the nanoscale (10 - 100 nm) 100317.6 particles per mg). The mean size of the nanoparticles was 45.5 nm, the mean size of particles in the range 10 - 417 nm was 218.8 nm.

The OPS (0.3 - 10 µm) counted 193.8 particles per cm3 corresponding to a dustiness index of 1101.1 particles per mg. The mean size of the particles was 4.4 µm.