Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-697-4 | CAS number: 124-40-3
The increase in lipoperoxidation may result in membrane damage and is further indicated by the labilisation of lysosomal enzymes.
The increased levels of the cytosolic SOD (superoxide dismutase) due to the administration of nitrite or DMA may indicate a higher generation of the superoxide radicals.
Nitrite, as well as DMA, caused higher in vitro lipoperoxidation, free lysosomal enzyme activities and cytosolic superoxide dismutase activity in liver. Some of these increases viz., the enzyme activities in liver, were counteracted to a significant extent in the rats receiving a dietary supplement of BHT (butylated hydroxytoluene). The results indicate that nitrite and DMA may induce toxicity through some free radical reactions and that BHT can provide some protection.
Nitrite and DMA, individually, cause significantly higher peroxidation. However, when fed together, the two chemicals do not elicit such a response and the lipoperox idative values of these animals are similar to those of the control.
In the nitrite-administered animals, the free activities of acid phosphatase and cathepsin were both increased, the change in acid phosphatase being statistically significant. In the DMA-administered rats a similar trend in both the enzymes is seen, the increase in cathepsin being more marked
The administration of nitrite or DMA appears to decrease the total activity of both the lysosomal enzymes.
In animals fed both nitrite and dimethylamine, the proportion of the free activity of both the enzymes is increased, in spite of a significant reduction in total activity. In these animals, BHT feeding affords marked protection and the increase in the percentage of free activities is restored to control levels.
Nitrite, both singly and in combination with DMA, significantly enhances the level of the enzyme in the supernatant. DMA alone, however, does not have any effect on SOD (superoxide dismutase) activity.
Likewise, rats administered nitrite and DMA are significantly protected against the increase in the enzyme activity, when their diet is supplemented with BHT (butylated hydroxytoluene).
The increased levels of the cytosolic SOD due to the administration of nitrite or DMA may indicate a higher generation of the superoxide radicals. The oxidation of haemoglobin by nitrite has been reported to involve the superoxide radicals.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again