Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

EC0(48h): 62.5 mg/L, EC50(48h): 88.67 mg/L, EC100(48h): 250 mg/L (BASF, 1988)
IC50(24h): 48 mg/L (Calamari et al., 1980)
EC50(24h): 98 mg/L, neutralised; EC50(24h): 286 mg/L, non-neutralised (Trenel and Kuhn, 1982)
EC50(48h): 50 mg/L (Van Leeuwen et al., 1985)

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
88.67 mg/L

Additional information

In the available key study dimethylamine was tested for possible acute ecotoxicological effects on Daphnia magna (BASF, 1988). The study was performed in accordance with EU Method C.2, exposure period lasted 48 hours. Evaluation of effects was performed after 24 and 48 hours. The test revealed the following results: EC0(48h): 62.5 mg/L, EC50(48h): 88.67 mg/L, EC100(48h): 250 mg/L.

Published information is also available (Calamari et al., 1980). Due to some deficiencies (e.g. test duration only 24 hours), the source is only regarded as supporting information. The experiment was done according to AFNOR, Norme Expérimentale N.F.T. 90-301 (1974) in order to test the acute toxicity of dimethylamine (and other amines) to aquatic invertebrate Daphnia magna. This test revealed an IC50 (immobilization concentration for 50 % of the animals at 24 h) value in hard water (320 mg CaCO3/L) of 48 mg/L.

In another experiment, Daphnia magna was used as test organisms to investigate the acute toxicity of the test substance after 24 hours (Trenel and Kuhn, 1982). Due to the shorter exposure time (24 h instead 48 h according to most test guidelines; e.g. OECD 202), the test has only limited validity. The substance was tested in its neutralised and non-neutralised form, resulting in EC50(24h) values of 98 mg/L and 286 mg/L, respectively.

Further investigation with Daphnia magna was performed by Van Leeuwen et al. (1985). The experiment was conducted according to OECD Guideline 202, using the pure substance as test material. A semi-static test regime was applied, whereby the test solutions were renewed every 24 hours. The total exposure duration was 48 hours, resulting in an EC50 value of 50 mg/L, based on mortality.