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EC number: 204-697-4 | CAS number: 124-40-3
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, no GLP compliance, sientifically acceptable
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- -0.274
- Temp.:
- 25 °C
- pH:
- 10.8 - 11.1
- Conclusions:
- A logPow of -0.274 (mean value, 3 measurements at different pH values) is reported for DMA.
- Endpoint:
- partition coefficient
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer-reviewed database; scientifically accepted calculation method
- Justification for type of information:
- QSAR prediction
- Principles of method if other than guideline:
- QSAR calculation procedure
- GLP compliance:
- not specified
- Type of method:
- other: QSAR
- Partition coefficient type:
- octanol-water
- Analytical method:
- not specified
- Type:
- log Pow
- Partition coefficient:
- -0.38
- Remarks on result:
- other: no further information given
- Conclusions:
- A very low logPow value of -0.38 was calculated, indicating low bioaccumulation potential of the test substance
- Executive summary:
A very low logPow value of -0.38 was calculated, indicating low bioaccumulation potential of the test substance.
- Endpoint:
- partition coefficient
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewd database; scientifically accepted calculation procedure
- Justification for type of information:
- QSAR prediction
- Principles of method if other than guideline:
- Peer reviewd database; scientifically accepted calculation procedure (according to Hansch & Leo)
- GLP compliance:
- no
- Type of method:
- other: QSAR calculation
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- -0.38
- Remarks on result:
- other: no further information given
- Conclusions:
- A very low logPow value of -0.38 was calculated, indicating low bioaccumulation potential of the test substance
- Executive summary:
A very low logPow value of -0.38 was calculated, indicating low bioaccumulation potential of the test substance.
Referenceopen allclose all
amine concentration |
Pow |
Log Pow |
pH |
||
c/(mol*L-1) |
c(octanol)/ c(water) |
|
|||
octanol- phase |
water- phase |
|
|
mean |
|
20.4 |
38.8 |
0.526 |
-0.279 |
-0.274 |
11.1 |
47.0 |
84.4 |
0.556 |
-0.255 |
10.9 |
|
5.42 |
10.56 |
0.513 |
-0.290 |
10.8 |
|
Description of key information
Partition coefficient (logPow): -0.274.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.274
- at the temperature of:
- 25 °C
Additional information
The octanol - water partition coefficient of dimethylamine was experimentally determined by BASF AG in 1988. At a temperature of 25 °C and in the pH range of 10.8 - 11.1 the substance possess a log Pow of -0.274.
Both impartial databases, HSDB and GESTIS, report a logPow of -0.38 for dimethylamine.
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