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Physical & Chemical properties

Partition coefficient

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Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, no GLP compliance, sientifically acceptable
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
-0.274
Temp.:
25 °C
pH:
10.8 - 11.1

amine concentration

Pow

Log Pow

pH

       c/(mol*L-1)

c(octanol)/

c(water)

 

octanol-

phase

water-

phase

 

 

mean

20.4

38.8

0.526

-0.279

 

-0.274

11.1

47.0

84.4

0.556

-0.255

10.9

5.42

10.56

0.513

-0.290

10.8

Conclusions:
A logPow of -0.274 (mean value, 3 measurements at different pH values) is reported for DMA.
Endpoint:
partition coefficient
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Peer-reviewed database; scientifically accepted calculation method
Justification for type of information:
QSAR prediction
Principles of method if other than guideline:
QSAR calculation procedure
GLP compliance:
not specified
Type of method:
other: QSAR
Partition coefficient type:
octanol-water
Analytical method:
not specified
Type:
log Pow
Partition coefficient:
-0.38
Remarks on result:
other: no further information given
Conclusions:
A very low logPow value of -0.38 was calculated, indicating low bioaccumulation potential of the test substance
Executive summary:

A very low logPow value of -0.38 was calculated, indicating low bioaccumulation potential of the test substance.

Endpoint:
partition coefficient
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Peer reviewd database; scientifically accepted calculation procedure
Justification for type of information:
QSAR prediction
Principles of method if other than guideline:
Peer reviewd database; scientifically accepted calculation procedure (according to Hansch & Leo)
GLP compliance:
no
Type of method:
other: QSAR calculation
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
-0.38
Remarks on result:
other: no further information given
Conclusions:
A very low logPow value of -0.38 was calculated, indicating low bioaccumulation potential of the test substance
Executive summary:

A very low logPow value of -0.38 was calculated, indicating low bioaccumulation potential of the test substance.

Description of key information

Partition coefficient (logPow): -0.274. 

Key value for chemical safety assessment

Log Kow (Log Pow):
-0.274
at the temperature of:
25 °C

Additional information

The octanol - water partition coefficient of dimethylamine was experimentally determined by BASF AG in 1988. At a temperature of 25 °C and in the pH range of 10.8 - 11.1 the substance possess a log Pow of -0.274.

Both impartial databases, HSDB and GESTIS, report a logPow of -0.38 for dimethylamine.