Registration Dossier

Toxicological information

Endpoint summary

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Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information
  • Negative Ames test (OECD 471)
  • Negative in vitro bacterial DNA damage / repair assay
  • Negative in vitro micronucleus assay
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Genetic toxicity in vivo

Description of key information
  • Negative in vivo mouse micronucleus test (OECD 487)
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

Justification for classification or non-classification

The results of in vitro gene mutation studies of TPP in bacteria, a bacterial DNA damage / repair assay, an in vitro human lymphocyte micronucleus assay, and an in vivo mouse micronucleus test were all negative. Therefore, it is concluded that TPP is not genotoxic and does not warrant classification for mutagenicity according to CLP Regulation EC 1272/2008.