[(methylethylene)bis(oxy)]dipropanol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study predates OECD guidelines and GLP, minor restrictions in design and reporting, but otherwise adequate for assessment.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Principles of method if other than guideline:

Neat tripropylene glycol was applied to the intact skin of the trunk of male albino rabbits for 24 h under occlusive dressing.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

[(methylethylene)bis(oxy)]dipropanol

EC Number:

246-466-0

EC Name:

[(methylethylene)bis(oxy)]dipropanol

Cas Number:

24800-44-0

Molecular formula:

C9H20O4

IUPAC Name:

1,1'-[propane-1,2-diylbis(oxy)]dipropan-1-ol

Details on test material:

- Name of test material (as cited in study report): Tripropylene glycol
- Substance type: organic
- Analytical purity: not specified
- Lot/batch No.: 06827
- Identification: S-145541
- CHF sample No: 37-61
- Date of receipt: 2-8-74

Test animals

Species:

rabbit

Strain:

other: albino

Sex:

male

Details on test animals or test system and environmental conditions:

The nonfasted animals were maintained on appropriate Rockland diets and water ad libitum except during period of manipulation or confinement. Rabbits were 3 to 5 months of age.

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

Test substance was applied undiluted under impervious sheeting on the clipped intact skin of the trunk. Animals were immobilized for 24 hour contact period.

Duration of exposure:

24 h

Doses:

16.0 ml/kg bw

No. of animals per sex per dose:

5 males/dose

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Statistics:

LD50 was calculated by the moving average method based on a 14-day observation period.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

> 16 320 mg/kg bw

Remarks on result:

other: Value in mg/kg bw was calculated based on the LD50 > 16 mL/kg bw and the relative density of the substance of 1.02.

Mortality:

There were no mortalities.

Clinical signs:

other: There were no clinical signs.

Gross pathology:

Livers mottled and acini prominent, spleens congested, kidneys pale and mottled.