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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restriction. Restriction: TS volume 0.05 mL instead of 0.1 mL

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
yes
Remarks:
TS volume 0.05 mL instead of 0.1 mL, no 72 h reading
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-aminoethylamino)ethanol
EC Number:
203-867-5
EC Name:
2-(2-aminoethylamino)ethanol
Cas Number:
111-41-1
Molecular formula:
C4H12N2O
IUPAC Name:
2-[(2-aminoethyl)amino]ethan-1-ol
Details on test material:
AEEA, degree of purity 99-100 %

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
physiological saline
Controls:
yes, concurrent vehicle
Amount / concentration applied:
TEST MATERIAL
- Amount applied: 0.05 mL
- Concentration: undiluted
Duration of treatment / exposure:
- single treatment
- the eyes were not washed out after 24 h
Observation period (in vivo):
8 days
Number of animals or in vitro replicates:
1 rabbit
Details on study design:
Scoring system: Draize

Tool used to assess score: hand-slit lamp / biomicroscope / fluorescein

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: erythema score
Basis:
animal #1
Time point:
other: 1, 24 hours
Score:
2
Max. score:
3
Reversibility:
not reversible
Remarks on result:
other: bleeding
Irritation parameter:
other: edema score
Basis:
animal #1
Time point:
other: 1, 24 hours
Score:
3
Max. score:
3
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other: bleeding
Irritation parameter:
other: opacity score
Basis:
animal #1
Time point:
other: 1, 24 hours
Score:
2
Max. score:
3
Reversibility:
not reversible
Remarks on result:
other: formation of pus and staphyloma after 8 days

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Executive summary:

In a primary eye irritation study (BASF XX / 174) a rabbit was exposed to 0.05 mL of AEEA (99 -100 %). The animal then was observed for 8 days. Irritation was scored after 1 and 24 hours by the method of Draize. The substance AEEA revealed moderate eye irritating effects in rabbits (edema score 3.0, erythema score 2.0, opacity score 2.0). Effects were not reversible within 8 days. The results in this study are in line with the corrosive properties of AEEA on the skin.