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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study was performed prior to the implementation of GLP and OECD Guidelines, but is in compliance with the principles described in OECD Guideline 403. Observation period is not reported.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not applicable
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-aminoethylamino)ethanol
EC Number:
203-867-5
EC Name:
2-(2-aminoethylamino)ethanol
Cas Number:
111-41-1
Molecular formula:
C4H12N2O
IUPAC Name:
2-[(2-aminoethyl)amino]ethan-1-ol
Details on test material:
AEEA, degree of purity 99-100 %

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Several groups of usually 3 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for different time periods ( 8 hours). The exposure time not causing lethality was usually testedtwice.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
saturated atmosphere at 20 °C.
No. of animals per sex per dose:
3 rats (total of 12 rats)
Control animals:
no
Details on study design:
- The animals were observed for signs of toxicity and mortality.
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC0
Effect level:
51.3 mg/m³ air
Exp. duration:
8 h
Remarks on result:
other: saturated atmosphere
Mortality:
No mortality (0/12) was seen.
Gross pathology:
Apart from strong eye irritation no findings were noted at necropsy.
Other findings:
- Other observations: Animals tried to escape upon start of exposure. 

Any other information on results incl. tables

Effect level:

Animals were exposed to AEEA in a saturated atmosphere at 20 °C. No exposure concentration was reported. As the vapour pressure of AEEA is 0.012 hPa at 20 °C (calculated), a saturated atmosphere corresponds to 51.3 mg/m³.

Applicant's summary and conclusion

Executive summary:

In this acute inhalation toxicity study a total of 12 rats (two times 3/sex) were whole body exposed to AEEA (saturated atmosphere at 20 °C) for 8 hours. Animals then were observed. Animals tried to escape upon start of exposure. No mortality occured. Apart from strong eye irritation no findings were noted at necropsy.