Registration Dossier
Registration Dossier
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EC number: 237-396-1 | CAS number: 13770-89-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature source
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Summary Tables of Biological Tests
- Author:
- National Research Council Chemical-Biological Coordination Center
- Year:
- 1 952
- Bibliographic source:
- 4: 320
- Reference Type:
- secondary source
- Title:
- Registry of Toxic Effects of Chemical Substances: Nickel (II) sulfamate
- Author:
- National Institute for Occupational Safety and Health
- Year:
- 2 008
- Bibliographic source:
- RTECS #QR9275000
Materials and methods
- Principles of method if other than guideline:
- Study design not reported
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Nickel bis(sulphamidate)
- EC Number:
- 237-396-1
- EC Name:
- Nickel bis(sulphamidate)
- Cas Number:
- 13770-89-3
- Molecular formula:
- Ni(NH2SO3)2
- IUPAC Name:
- nickel(2+) disulfamate
- Details on test material:
- - Name of test material (as cited in study report): nickel (II) sulfamate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not Reported
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: isotonic saline
- Details on exposure:
- Not Reported
- Doses:
- 500, 250, 125, 62.5, 31.3 mg/kg
- No. of animals per sex per dose:
500 mg/kg: 5
250 mg/kg: 3
125 mg/kg: 3
62.5 mg/kg: 3
31.3 mg/kg: 3
(sex not reported)- Control animals:
- not specified
- Details on study design:
- Not Reported
- Statistics:
- Not Reported
Results and discussion
- Mortality:
- 500 mg/kg: 5/5 (day of death: 1 animal at 5 minutes, 3 at 15 minutes, one at 3 days)
250 mg/kg: 2/3 (day of death: day 3 for both animals)
125 mg/kg: 0/3
62.5 mg/kg: 0/3
31.3 mg/kg: 0/3 - Clinical signs:
Animals in the high dose group (500 mg/kg) exhibited dyspnea and straining- Body weight:
- Not Reported
- Gross pathology:
- Not Reported
- Other findings:
- Not Reported
Any other information on results incl. tables
Not Applicable
Applicant's summary and conclusion
- Conclusions:
Not Applicable (data insufficient)- Executive summary:
STUDY RATED BY AN INDEPENDENT REVIEWER
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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