Registration Dossier
Registration Dossier
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EC number: 222-048-3 | CAS number: 3327-22-8
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The test was carried out according to the appropriate OECD test guideline and in compliance with GLP. However, no chemical analysis was performed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- (3-chloro-2-hydroxypropyl)trimethylammonium chloride
- EC Number:
- 222-048-3
- EC Name:
- (3-chloro-2-hydroxypropyl)trimethylammonium chloride
- Cas Number:
- 3327-22-8
- Molecular formula:
- C6H15ClNO.Cl
- IUPAC Name:
- 3-chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride
- Reference substance name:
- (3-chloro-2-hydroxypropyl)trimethylammoniumchloride
- IUPAC Name:
- (3-chloro-2-hydroxypropyl)trimethylammoniumchloride
- Details on test material:
- 65.44 % 3-chloro-2-hydroxypropyltrimethylammoniumchloride was used. The purity of the QUAB 188 was 96.64 %.
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Nominal and measured concentrations:
- Nominal concentrations 1.000, 1.800, 3.200, 5.600 and 10.000 of QUAB 188 mg/L
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2 094 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4 128 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 6 544 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Reported statistics and error estimates:
- The LC50 values and their confidence interval were calculated by means of a parametric model developed by Kooijman (1981).
Any other information on results incl. tables
- Sublethal observations / clinical signs:
NOEC 3200 mg (2094 mg/l), but in concentration 1800 mg/l (1178 mg/l) one fish died (the death is assumed to be accidental).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 96 h EC50 value of 4128 mg a.i./L has been determined for the effects of the test substance on mortality of B. rerio.
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