Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:
Migrated from Short description of key information:
Cobalt bis(2-ethylhexanoate) will be classified as skin sensitiser according to section 3.4, annex I of regulation (EC) 1272/2008 based on animal data from the read-across substance cobalt (II) 4-oxopent-2-en-2-olate showing a similar bioaccessibility in artificial perspiration (read-across group of short chain carboxylates (C<10) with similar bioavailability). For further information please refer to the document attached to the endpoint summary in IUCLID section 7.4 (Sensitisation)or Appendix 2 of the CSR.

Justification for selection of skin sensitisation endpoint:
Key study

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:
Migrated from Short description of key information:
There is no known direct experience or information implicating this substance as occupational respiratory sensitiser. Furthermore, the pure substance is a waxy solid which is not capable in creating an inhalable atmosphere, thus respiratory sensitisation can safely be excluded for this substance.

Justification for selection of respiratory sensitisation endpoint:
Weight of evidence information

Justification for classification or non-classification

Sensitisation

Cobalt bis(2-ethylhexanoate) will be classified as skin sensitiser according to section 3.4, annex I of regulation (EC) 1272/2008 based on animal data from the read-across substance cobalt (II) 4 -oxopent-2 -en-2-olate showing a similar bioaccessibility in artificial perspiration (read-across group of short chain carboxylates (C<10) with similar bioavailability). Cobalt bis(2-ethylhexanoate) will be classified as skin sensitiser category 1A (H317). Thus further testing is not required, according to section 1.1.3 and 1.2, annex XI of regulation (EC) 1907/2006.

 

Respiratory sensitisation

The pure substance is a waxy solid which is not capable in creating an inhalable atmosphere, thus respiratory sensitisation can safely be excluded for this substance. Experimental testing is technically not feasible.