Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-250-6 | CAS number: 136-52-7
Results after treatment with cobalt 2-ethylhexanoate:
Absorbance 570 nm Tissue 1
Absorbance 570 nm Tissue 2
Absorbance 570 nm Tissue 3
Mean Absorbance of 3 Tissues
Relative Absorbance [%] Tissue 1, 2 + 3
Mean Rel. Absorbance
[% of Negative Control]
Number of Studies
July 2007-June 2010
Range of Viabilities
Range of ODs
Reference Heppenheimer (2010) is considered as the key study for skin corrosion and will be used for classification. The overall irritation results in an in vitro human skin model test (according to OECD 431) are as follows:
Relative viability 3 min after treatment: 106.9 %
Relative viability 60 min after treatment: 80.7 %
The classification criteria according to regulation (EC) 1272/2008 as corrosive to skin are not met since the relative viability after 3 and 60 minutes exposure was above 50 % and 15% respectively, hence cobalt bis(2-ethylhexanoate) will not be classified as skin corrosive.
Reference Heppenheimer (2011) is considered as the key study for skin irritation and will be used for classification. The mean relative absorbance (% of the negative control, correlating with mean tissue viability) after 15 minutes incubation in the in vitro human skin model test (EpiSkin, according to OECD TG 439) was 88.0%.
The classification criteria according to regulation (EC) 1272/2008 as skin irritant are not met, since the mean tissue viability was above the threshold for skin irritants of 50.0%. No classification required.
The references Heppenheimer (2011) and Mallaun (2011) are considered as the key studies for severe eye irritation and will be used for classification.
According to Heppenheimer (2011) the mean in vitro score after 240 minutes incubation results of the in vitro bovine corneal opacity and permeability assay (BCOP, according to OECD TG 437) was 0. The value was below the threshold for severe eye irritants of 55.1. The classification criteria according to regulation (EC) 1272/2008 as severe eye irritation are not met, hence no classification required.
According to Mallaun (2011) the overall irritation results 24, 48 and 72 hours after application per animal are as follows:
- Corneal opacity = 0.00, 1, 1
- Iris light reflex = 0.00 for all three animals
- Conjunctival redness = 1.00, 3.00, 2.33
- Conjunctival oedema = 0.00, 1.33, 1.33
The classification criteria acc. to regulation (EC) 1272/2008 as irritating to eyes are met, since corneal opacity was above the threshold of
≥ 1 and conjunctival redness was above the threshold of ≥ 2 as well as the effect were fully reversible within 14 days. Thus, cobalt bis(2 -ethylhexanoate will be classified as eye irritant category 2 (H319).
The justification for non classification as respiratory irritant is covered under the endpoint specific target organ toxicity- single exposure: inhalation as given in the acute toxicity section.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again