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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction

Currently viewing:

Administrative data

Endpoint:
fertility, other
Remarks:
based on test type (migrated information)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited documentation; endpoint record transferred from IUCLID 4

Data source

Reference
Title:
No information
Author:
Telford, I.R. et al., Am. J. Anat. 110, 29-36 (1962)

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
EC Number:
500-051-3
EC Name:
1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
Cas Number:
26780-96-1
Molecular formula:
(C12H15N)x
IUPAC Name:
2,2,4-trimethyl-1,2-dihydroquinoline
Constituent 2
Reference substance name:
quinoline, 1,2-dihydro-2,2,4-trimethyl-, homopolymer
IUPAC Name:
quinoline, 1,2-dihydro-2,2,4-trimethyl-, homopolymer

Test animals

Species:
rat
Strain:
other: Walter Reed-Carworth Farms
Sex:
female

Administration / exposure

Route of administration:
oral: feed
Duration of treatment / exposure:
Exposure period: 22 d
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
250 mg/animal, total dose (= ca. 56.8 mg/kg bw/d)
Basis:

Control animals:
yes

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
no maternal toxicity, no increase in the resorptions-rate

Applicant's summary and conclusion