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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited documentation; endpoint record transferred from IUCLID 4

Data source

Reference
Title:
No information
Author:
Unpublished data, Southern Research Institute; copy from the|NTP study files, enclosure of a letter from Eastin, W. dated|September 2, 1994

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
EC Number:
500-051-3
EC Name:
1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
Cas Number:
26780-96-1
Molecular formula:
(C12H15N)x
IUPAC Name:
2,2,4-trimethyl-1,2-dihydroquinoline
Details on test material:
IUCLID4 Test substance: no data

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Route of administration:
other: skin painting
Duration of treatment / exposure:
14 days
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
2, 20, 200, 1000 and 2000 mg/kg bw
Control animals:
yes, concurrent no treatment
Details on study design:
Post-exposure period: no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
no mortality; mean terminal body weight reduction 
(>=200 mg/ kg (m/f), 20 mg/kg (f)); the principal gross
lesion was scaly skin at treatment site (> 2 mg/kg);
histopathological lesions of the treated skin (>= 20 mg/kg
both sexes) and thyroid (>= 200 mg/kg both sexes;
hyperplasia, follicular cell) (no further information
available from the abstract)

Applicant's summary and conclusion