Registration Dossier
Registration Dossier
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EC number: 500-051-3 | CAS number: 26780-96-1
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited documentation; endpoint record transferred from IUCLID 4
Data source
Reference
- Title:
- No information
- Author:
- Unpublished data, Southern Research Institute; copy from the|NTP study files, enclosure of a letter from Eastin, W. dated|September 2, 1994
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
- EC Number:
- 500-051-3
- EC Name:
- 1,2-Dihydro-2,2,4-trimethylquinoline, oligomers
- Cas Number:
- 26780-96-1
- Molecular formula:
- (C12H15N)x
- IUPAC Name:
- 2,2,4-trimethyl-1,2-dihydroquinoline
- Details on test material:
- IUCLID4 Test substance: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: skin painting
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2, 20, 200, 1000 and 2000 mg/kg bw
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Post-exposure period: no data
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
no mortality; mean terminal body weight reduction
(>=200 mg/ kg (m/f), 20 mg/kg (f)); the principal gross
lesion was scaly skin at treatment site (> 2 mg/kg);
histopathological lesions of the treated skin (>= 20 mg/kg
both sexes) and thyroid (>= 200 mg/kg both sexes;
hyperplasia, follicular cell) (no further information
available from the abstract)
Applicant's summary and conclusion
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