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Key value for chemical safety assessment

Additional information

Disodium persulfate was tested for genetic toxicity in two in vitro tests. A gene mutation assay with bacteria (Ames test) according to FIFRA guideline 84-1 was negative. An unscheduled DNA synthesis test with rat liver hepatocytes according to FIFRA guideline 84-2 showed no signs of mutagenic activity. Disodium persulfate was tested in two in vivo tests for mutagenic activity. In the mouse micronucleus test, no mutagenic activity could be detected, as well as in an in vivo unscheduled DNA synthesis assay in rat livers. Based on the obtained results, disodium persulfate was considered not genotoxic.

Of the Persulfate Category, disodium persulfate was tested for genetic toxicity in two in vitro tests and in two in vivo tests. Results of in vitro tests, an Ames test and an unscheduled DNA synthesis test with rat liver hepatocytes showed no signs of mutagenic activity. Results of in vivo tests with disodium persulfate showed no clastogenic effect in a mouse micronucleus test and no mutagenic activity in an in vivo unscheduled DNA synthesis assay in rat livers. Thus, disodium persulfate was considered not genotoxic. As all substances of the Persulfate Category share the same anionic persulfate moiety and similar toxicological properties a read across approach was applied for diammonium persulfate and dipotassium persulfate using results obtained with disodium persulfate. Diammonium persulfate and dipotassium persulfate were not considered genotoxic.


Short description of key information:
Disodium persulfate was tested for genetic toxicity in in vitro and in vivo studies. Based on the results obtained, disodium persulfate was considered not genotoxic. No additional data were available from substances of the Persulfate Category (diammonium persulfate and dipotassium persulfate).

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on the results obtained, substances of the Persulfate Category were not classified and labelled for genetic toxicity according to Regulation (EC) No 1272/2008.