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Administrative data

Description of key information

Disodium persulfate was tested for repeated dose oral toxicity in rats in a 90-day subchronic study. LOAEL and NOAEL values of 200 mg/kg bw/day and 91 mg/kg bw/day were determined, respectively. In addition Persulfate Category data was available. Read across data included a NOAEL of 131.5 mg/kg bw/day for subacute oral toxicity and a NOAEC of 10.3 mg/m³ for subchronic inhalation toxicity for dipotassium persulfate and diammonium persulfate, respectively. Repeated dose toxicity via the dermal route was waived, but a NOEAL calculated for chemical risk assessment resulting in a dermal NOAEL of 91 mg/kg bw/day assuming 100 % absorption through the skin.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEL
91 mg/kg bw/day
Study duration:
subchronic

Additional information

Disodium persulfate was tested for repeated dose toxicity in rats in a 90-day study. All animals survived during the study. LOAEL and NOAEL values of 200 mg/kg bw/day (3000 ppm) and 91 mg/kg bw/day (1000 ppm) respectively, were determined. Intestinal changes (examined microscopically) were noted among the rats which received 3000 ppm of sodium persulfate for 13 weeks, considered local primary effects while significant differences in body weight and food consumption in this dose group were considered secondary systemic effects. In addition read-across data for substances of the Persulfate Category was available. All substances of the Persulfate Category share the same anionic persulfate moiety and similar toxicological properties. Repeated dose toxicity data was available for diammonium persulfate and dipotassium persulfate. Of the Persulfate Category, dipotassium persulfate and diammonium persulfate were tested for subacute oral repeated dose toxicity, resulting in NOAEL values of 131.5 mg/kg bw/day and 41.1 mg/kg bw/day. The apparent difference in subacute toxicity of persulfates was considered to be due to the ammonium cation and its effects. Diammonium persulfate, when dissociated in solution, exists as simple alkali metal cation and persulfate anion, with the ammonium cation in equilibrium with ammonia depending on the solution’s pH. Dissolution of ammonium persulfate itself will also affect pH. This may complicate the toxicological profile of ammonium persulfate (EC JRC IHCP Report, 2007). Disodium persulfate was tested in a subchronic 90-day inhalation toxicity study. A NOAEC value of 10.3 mg/m³ was determined. Repeated dose toxicity via the dermal route was waived, but a NOEAL calculated for chemical risk assessment resulting in a dermal NOAEL of 91 mg/kg bw/day assuming 100 % absorption through the skin. Worst-case values considered for safety assessment were: Repeated dose oral (NOAEL): 91 mg/kg bw/day

Repeated dose dermal (NOAEL): 91 mg/kg bw/day

Repeated dose inhalation (NOAEC): 10.3 mg/m³


Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: duodenum

Justification for classification or non-classification

Based on the results obtained, substances of the Persulfate Category were not classified and labelled for repeated dose toxicity according to Directive 67/548/EEC (DSD) and Regulation 1272/2008/EC (CLP).