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EC number: 231-892-1 | CAS number: 7775-27-1
Dose [mg/kg p.o.]
Disodium persulfate was tested for toxicity by oral application in male and female Sprague Dawley rats. No guideline was specified. Ten male and ten female Sprague-Dawley rats per group were dosed with 215, 464, 562, 681, 825, 1000, 1210 and 1470 mg/kg bw disodium persulfate and were observed for 4 weeks. Clinical signs and mortalities were recorded. All animals were subjected to gross autopsy after termination of the study. No animal died in the lowest dose group (215 mg/kg bw), two rats (one male and one female rat) died in the intermediate dose group (681 mg/kg bw) and all rats died in the highest dose group (1470 mg/kg bw). Death occurred within 60 minutes until 6 days after application. Surviving animals had recovered after 48 hours after application. Clinical signs included sedation, dyspnoea, diarrhoea, muscular hypotension, reduced feed intake and face-down position. LD50-values of 930 mg/kg bw (males) and 920 mg/kg bw (females) were determined after a 14 days observation period and corresponding LD0 values of 464 mg/kg in male rats and 562 mg/kg in female rats were revealed.
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