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Administrative data

Description of key information

Disodium persulfate was tested for acute toxicity via the oral, dermal and inhalation routes. LD50 and LD0 values of 895 mg/kg bw and 500 mg/kg bw, respectively, were determined in an acute oral toxicity study in male rats. In a dermal toxicity study LD50 and LD0 values of greater than 10000 mg/kg bw and 10000 mg/kg bw, respectively, were determined. In an inhalation toxicity study with disodium persulfate study LC50 and LC0 values of greater than 5.1 mg/L and 5.1 mg/L, respectively were determined. Additional studies were available for substances of the Persulfate Category, diammonium persulfate and dipotassium persulfate.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
895 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
5 100 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
10 000 mg/kg bw

Additional information

Disodium persulfate was tested for acute oral dermal and inhalation toxicity. Disodium persulfate was tested for acute oral toxicity in male rats. LD50 and LD0 values of 895 mg/kg bw and 500 mg/kg bw, respectively, were determined.

In a dermal toxicity non-GLP study in male rabbits the LD50 and LD0 values of greater than 10000 mg/kg bw and 10000 mg/kg bw were determined.

Disodium persulfate was tested in a 4-hour nose-only inhalation study with rats according to EU guideline B.2. The acute LC50 and LC0 values were determined to be greater than 5.1 mg/L and 5.1 mg/L, respectively, for male and female rats.

Of the Persulfate Category, diammonium persulfate and dipotassium persulfate were tested as well for acute oral, acute dermal and acute inhalation toxicity.

For diammonium persulfate and dipotassium persulfate LD50 values of 700 mg/kg bw and 1130 mg/kg bw, respectively, were determined in acute oral toxicity studies. In acute dermal toxicity studies, LD50 and LD0 values of greater than 2000 mg/kg bw and 2000 mg/kg bw, respectively, were determined for diammonium persulfate and LD50 and LD0 of greater than 10000 mg/kg bw and 10000 mg/kg bw, respectively were determined foe dipotassium persulfate. In acute inhalation toxicity studies LC50 and LC0 of greater than 2.95 mg/L and 2.95 mg/L, respectively were determined for diammonium persulfate. LC50 and LC0 values of greater than 42.9 mg/L and 42.9 mg/L, respectively were determined for dipotassium persulfate.

For the Persulfate Category worst-case values obtained were considered for safety assessment:

LD0 (oral): 300 mg/kg bw

LD0 (dermal): 2000 mg/kg bw

LC0 (inhalation): 2950 mg/m³.

Justification for classification or non-classification

Based on the results obtained, substances of the Persulfate Category were classified and labelled Xn, R 22 (harmful if swallowed), according to Directive 67/548/EEC (DSD) and acute toxic, cat. 4 H302 (harmful if swallowed) according to Regulation 1272/2008/EC (CLP).