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Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reason / purpose for cross-reference:
read-across source
Key result
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
20.8 mg/L
Nominal / measured:
nominal
Conc. based on:
other: APS
Basis for effect:
reproduction
Key result
Duration:
21 d
Dose descriptor:
EC10
Effect conc.:
25.9 mg/L
Nominal / measured:
nominal
Conc. based on:
other: APS
Basis for effect:
reproduction

Description of key information

The long-term toxicity of the Persulfate Category to aquatic invertebrates was tested with diammonium peroxodisulphate (APS). Based on the results of this 21-day chronic toxicity study, the test item had significant influence on the reproductive output of Daphnia magna. The determined NOEC and LOEC based on nominal concentrations for reproduction were 20.8 mg/L and 39.5 mg/L. An EC10 and EC50 of 25.9 mg/L (95 % confidence limit: 9.7 - 35.1 mg/L) and 44.0 mg/L (95 % confidence limit: 31.5 - 67.8 mg/L) for reproduction was observed, respectively. For mortality a NOEC value of 39.5 mg/L and a LOEC value of 75.0 mg/L was observed.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
25.9 mg/L

Additional information

The influence of the test item Diammonium peroxodisulphate (APS) on the reproductive output of Daphnia magna was observed in a 21-day chronic toxicity study according to OECD guideline 211, EU method C.20 and OPPTS 850.1300. In a semi static test system, young female Daphnia were exposed to aqueous test media containing the test item for 21 days at the nominal test item concentrations of 3.0, 5.8, 10.9, 20.8, 39.5 and 75.0 mg/L. The analytically measured test item concentrations remained within ± 20 % of the nominal, therefore the biological results are based on the nominal concentrations.

No significant inhibition in reproduction was noticed in the concentrations of 3.0, 5.8, 10.9 and 20.8 mg/L. The total number of living offspring per parent animal reduced significantly compared to the control in the two highest concentrations of 39.5 and 75.0 mg/L. No considerable mortality of parents (up to 20 %) was observed in the control and in the concentrations of 3.0, 5.8, 10.9, 20.8 and 39.5 mg/L and all parent animals died during the test in the highest concentration of 75.0 mg/L.

Based on the results of this 21-day chronic toxicity study, the test item had significant influence on the reproductive output of Daphnia magna.

The determined NOEC and LOEC based on nominal concentrations for reproduction were 20.8 mg/L and 39.5 mg/L. An EC10 and EC50 of 25.9 mg/L (95 % confidence limit: 9.7 - 35.1 mg/L) and 44.0 mg/L (95% confidence limit: 31.5 - 67.8 mg/L) for reproduction was oberseved, respectively. For mortality a NOEC vaule of 39.5 mg/L and a LOEC value of 75.0 mg/L was observed.

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