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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Data from secondary source (peer-reviewed handbook). The data are reported to be unpublished, original data of the author (Fasset) from the Laboratory of Industrial Medicine, Eastman Kodak Co., Rochester NY Insufficient information to determine reliability

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1963

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: not known
Principles of method if other than guideline:
other
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl methacrylate
EC Number:
211-708-6
EC Name:
2-ethylhexyl methacrylate
Cas Number:
688-84-6
Molecular formula:
C12H22O2
IUPAC Name:
2-ethylhexyl methacrylate
Test material form:
liquid
Specific details on test material used for the study:
Test substance cited as 2-ethyl isohexylmethacrylate but in Clayton and Clayton (1981) quoted as CAS 688-84-6.

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 20 mL/kg bw
Remarks on result:
other: 17620 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
A published LD50 >20 ml/kg bw in guinea pigs is available.
Executive summary:

A published LD50 >20 ml/kg bw in guinea pigs is available.