Registration Dossier
Registration Dossier
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EC number: 201-114-5 | CAS number: 78-40-0
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficent documented for evaluation
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Cytogenetic effects induced by organophosphorus pesticides in mouse spermatocytes
- Author:
- Degraeve N, Chollet AC, Moutschen J
- Year:
- 1 984
- Bibliographic source:
- Toxicol Lett 21, 315-319
- Reference Type:
- publication
- Title:
- Mutagenic effects induced by organophosphorus compounds
- Author:
- Degraeve N, Chollet MC, Moutschen J
- Year:
- 1 986
- Bibliographic source:
- J Toxicol Clin Exp
Materials and methods
- Principles of method if other than guideline:
- Male mice (Q-strain) received a single ip injection of triethyl phosphate. The cytogenetic effects were investigated in bone marrow cells and spermatogonia.
- GLP compliance:
- not specified
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- Triethyl phosphate
- EC Number:
- 201-114-5
- EC Name:
- Triethyl phosphate
- Cas Number:
- 78-40-0
- Molecular formula:
- C6H15O4P
- IUPAC Name:
- triethyl phosphate
- Details on test material:
- Triethyp phosphate was suplied by Merck-Schuchardt
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Q-Strain
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 12 to 36 hours or 10 to 15 days
- Frequency of treatment:
- single injection
- Post exposure period:
- no
Doses / concentrations
- Remarks:
- Doses / Concentrations:
300 mg/kg bw
Basis:
nominal conc.
- No. of animals per sex per dose:
- 20 animals
- Control animals:
- yes
Examinations
- Tissues and cell types examined:
- bone marrow cells and spermatogonia
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Any other information on results incl. tables
The frequency of chromosome aberrations observed in bone marrow metaphases and spermatogonia of the animals treated with triethyl phophate did not increase significantly with respect to the control levels
Applicant's summary and conclusion
- Executive summary:
Male mice (Q-strain) received a single ip injection of triethyl phosphate. The cytogenetic effects were investigated in bone marrow cells and spermatogonia.
The frequency of chromosome aberrations observed in bone marrow metaphases and spermatogonia of the animals treated with triethyl phophate did not increase significantly with respect to the control levels.
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