Triethyl phosphate

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

sub-chronic toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: secondary literature

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Letter to US EP cited in BUA 37

Author:

Eastman Kodak Co

Year:

1984

Bibliographic source:

Doc ID 86-910000057 cited in BUA 37

Reference 2

Reference Type:

review article or handbook

Title:

Triethylphosphat BUA Stoffbericht 37 (Maerz 1989)

Author:

Anon

Year:

1989

Bibliographic source:

Beratergremium für umweltrelevante Altstoffe (BUA) d. Ges. Dt. Chemiker, Weinheim, Basel (Schweiz), Cambridge, New York, NY: VCH 1989 (Bua Stoffbericht 37)

Materials and methods

Principles of method if other than guideline:

Three groups of 5 male rats were exposed by inhalation to aerosol concentrations of 0, 366, or 1786 mg/m³ of the test substance 5 h/day, 5 days/week for a total of 12 exposures. About 35% of the test atmosphere was respirable.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Triethyl phosphate

EC Number:

201-114-5

EC Name:

Triethyl phosphate

Cas Number:

78-40-0

Molecular formula:

C6H15O4P

IUPAC Name:

triethyl phosphate

Details on test material:

no data

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

not specified

Vehicle:

other: no data

Remarks on MMAD:

MMAD / GSD: no data

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

12 weeks

Frequency of treatment:

5 h/day, 5 days per week

Doses / concentrations

Remarks:

Doses / Concentrations:
0, 366, or 1786 mg/m³
Basis:
no data

No. of animals per sex per dose:

5

Control animals:

yes

Results and discussion

Effect levels

Dose descriptor:

NOAEC

Effect level:

366 mg/m³ air

Sex:

male

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

Abnormal clinical signs in the high-exposure group included lethargy, decreased aural response, unsteady gait, and porphyrin nasal discharges which resolved prior to subsequent exposures. No abnormal clinical signs were seen in the low-dose group. Weight gain, hematology, clinical chemistry, and gross and histopathology were unremarkable at both dose levels. Slightly increased (17 -19%) absolute and relative (to body weight) liver weights were noted in the high-exposure group, but these were not considered toxicologically significant in the absence of histopathology or clinical chemistry changes.

Applicant's summary and conclusion

Executive summary:

Three groups of 5 male rats were exposed by inhalation to aerosol concentrations of 0, 366, or 1786 mg/m³ of the test substance 5 h/day, 5 days/week for a total of 12 exposures. About 35% of the test atmosphere was respirable.

A NOAEL = 366 mg/m³ was observed.