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Description of key information

In guideline studies triethyl  phosphate was tested for skin irritation/corrosion and eye irritation. The test substance was found to be not irritating to the skin and irritating to the eyes of rabbits.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study.
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes
Species:
rabbit
Strain:
New Zealand White
Type of coverage:
semiocclusive
Preparation of test site:
abraded
Vehicle:
unchanged (no vehicle)
Controls:
yes
Amount / concentration applied:
500 µl
Duration of treatment / exposure:
4 h
Observation period:
7 d
Number of animals:
3 , female
Details on study design:
experimental animals served also as control animals: the contralateral skin area not treated with test substance served as control.
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: No irritation / corrosion observed
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: No irritation / corrosion observed
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: No irritation / corrosion observed
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: No irritation / corrosion observed
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: No irritation / corrosion observed
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: No irritation / corrosion observed
Other effects:
no data

No irritation/ corrosion observed.

Executive summary:

The irritant/ corrosive effects of the test substance TEP were tested on the skin of female rabbits in accordance with the OECD Guideline No. 404 for testing Chemicals.

The substance was not irritating to the skin (exposure period: 4 hrs).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study.
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes
Species:
rabbit
Strain:
New Zealand White
Controls:
yes
Amount / concentration applied:
100 µl
Duration of treatment / exposure:
24 h
Observation period (in vivo):
21 d
Number of animals or in vitro replicates:
3, female
Irritation parameter:
cornea opacity score
Basis:
animal #1
Remarks:
D38
Time point:
24/48/72 h
Score:
1.7
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
cornea opacity score
Basis:
animal #2
Remarks:
F21
Time point:
24/48/72 h
Score:
1.7
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
cornea opacity score
Basis:
animal #3
Remarks:
D33
Time point:
24/48/72 h
Score:
1.7
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
iris score
Basis:
animal #1
Remarks:
D38
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: See table of results
Irritation parameter:
iris score
Basis:
animal #2
Remarks:
F21
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: See table of results
Irritation parameter:
iris score
Basis:
animal #3
Remarks:
D33
Time point:
24/48/72 h
Score:
0
Remarks on result:
other: See table of results
Irritation parameter:
conjunctivae score
Basis:
animal #1
Remarks:
D38
Time point:
24/48/72 h
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
conjunctivae score
Basis:
animal #2
Remarks:
F21
Time point:
24/48/72 h
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
conjunctivae score
Basis:
animal #3
Remarks:
D33
Time point:
24/48/72 h
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
chemosis score
Basis:
animal #1
Remarks:
D38
Time point:
24/48/72 h
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
chemosis score
Basis:
animal #2
Remarks:
F21
Time point:
24/48/72 h
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Irritation parameter:
chemosis score
Basis:
animal #3
Remarks:
D33
Time point:
24/48/72 h
Max. score:
2
Reversibility:
fully reversible within: 7d
Remarks on result:
other: See table of results
Other effects:
see: remarks on results

Test for irritant effect on the eye (expos.24 h)


 
























































































































































































































































































































































































 Animal No: (body weight) tissue signs DRAIZE grades                   Irrit. index
    1h 24h 48h 72h 7d 14d 21d 
 D38, female (3,8 kg) cornea o 1 2 2 1 0 0 0 1,7
   a 4 4 4 40  0 0 
 fluorescein i - 1 2 1 0 - - 
   a - 4c 3c 2c 0 - - 
  iris  0 0 0 0 0 0 0 0,0
 conjunctivae r 0 2 2 2 0 0 0 2,0
   s 3 2 0 0 0 0 0 0,7
 aqueoushumour 0 0 0 0 0 0 0 0 
  discharge 3 3 2 2 0 0 0 0 
 F21, female(3,7 kg) cornea o 1 2 2 1 0 0 0 1,7
   a 4 4 4 4 0 0 0 
  fluorescein i - 1 1 1 0 - - 
   a - 4c 3c 1c 0 - - 
  iris  0 0 0 0 0 0 0 0,0
  conjunctivae r 0 2 2 2 0 0 0 2,0
   s 4 20  0 0 0 0 1,7
  aqueous humour  0 0 0 0 0 0 0 
  discharge  3 3 1 1 0 0 0 
 D33, female(3,6 kg) cornea o 1 2 2 1 1 1 0 1,7
   a 4 4 4 4 32  0 
  fluorescein i - 1 2 1 1 0 0 
   a - 3c 4c 4c1c  0 0 
  iris  0 0 0 0 0 0 0 0,0
  conjunctivae r 0 2 2 2 0 0 0 2,0
   s 3 0 0 0 0 0 0 0,0
  aqueous humour  0 0 0 0 0 0 0 
  discharge  3 3 1 1 0 0 0 

 


o = opacity


a = area


i = intensity


r = redness


s = swelling


- = not examined


c = confluent diffuse areas

Interpretation of results:
moderately irritating
Remarks:
Migrated information
Executive summary:

The irritant effects of the test substance TEP were tested in an eye irritation study in rabbits in accordance with the OECD Guideline No. 405.

The substance was moderately irritating to the eye (exposure period: 24 hrs) with a mean conjuctivae score of 2.0.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The test substance was tested in a skin irritation/corrosion test in rabbits according to OECD 404. The test substance (500 µl) was administered via patch to the skin of one flank and remained there for 4 hours. The other flank served as control. The animals were observed for 14 days after experiment. Mean value for erythema after DRAIZE-grade was: 0.0; mean value for edema: 0.0. The test substance was found to be not irritating.

The test substance was tested in an eye irritation test in rabbits according to OECD 405. The test substance (100 µl) was administered into one eye of 3 rabbits (the other eye remained untreated and served as control). The substance was washed out after 24 hours. The animals were observed for 21 days after exposure. Mean value for cornea opacity after DRAIZE-grade was: 1.7; mean value for conjuctivae (redness): 2.0;

mean value for conjuctivae (chemosis): 0.44; iris: 0.0.

The test substance was found to be irritating to the eyes according to GHS. the substance has to be classified as Eye Irrit. 2; H319


Justification for selection of skin irritation / corrosion endpoint:
The most reliable study was used as key study and for classification.

Justification for selection of eye irritation endpoint:
The most reliable study was used as key study and for classification.

Justification for classification or non-classification

Based on the results of a skin irritation study performed according to OECD 404 no classification is warranted.

In an eye irritation study performed according to OECD 405 the mean value was for cornea opacity: 1.7; mean value for conjuctivae (redness): 2.0; mean value for conjuctivae (chemosis): 0.44; iris: 0.0.

The test substance was found to be moderatly irritating. According to GHS the substance has to be classified as Eye Irrit. 2; H319