Triethyl phosphate

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: No OECD guideline study or GLP defined. Unpublished company data (1968).

Data source

Reference

Reference Type:

other: unpublished company data

Title:

Unnamed

Year:

1968

Materials and methods

Type of study / information:

unpublished company data

Principles of method if other than guideline:

Identification of Cholinesterase activity in plasma and erythrocytes after oral administration of TEP in Beagle dogs.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Triethyl phosphate

EC Number:

201-114-5

EC Name:

Triethyl phosphate

Cas Number:

78-40-0

Molecular formula:

C6H15O4P

IUPAC Name:

triethyl phosphate

Details on test material:

no data

Results and discussion

Any other information on results incl. tables

		Inhibition of Cholinesterase in %
Dose (mg/kg)	Dog No.:	before experimental start	after 2 h	after 6 h	after 24 h	after 3 d	after 7 d
Plasma
100	35	0	0	13,7	10,3	<5	<5
100	36	0	0	14,5	9,5	0	0
250	41	0	22,5	53,3	27,5	10	<5
250	41	0	50,8	48,5	35,8	12,4	<5
Erythrocytes
100	35	0	0	0	0	0	0
100	36	0	0	0	0	0	0
250	41	0	0	<5	10,4	9	<5
250	42	0	0	12	6,0	<5	<5

Applicant's summary and conclusion

Executive summary:

The activity of Cholinesterase was measured in plasma and erythrocytes of dogs treated with TEP.

TEP was administered orally in a 10% aqueous dilution and after 2, 6, 24 h, 3d and 7d the activity of Choolinesterase was measured.

Every dose was tested in two dogs.

TEP inhibits the unspecific plasma-cholinesterase in dogs after administration of 250 mg/kg bw (100 mg/kg bw showed no significant effect).

The erythrocytes-cholinesterase was not inhibited after administration of 100 or 250 mg/kg in dogs.