Registration Dossier
Registration Dossier
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EC number: 202-951-9 | CAS number: 101-54-2
Endpoint summary
Administrative data
Description of key information
Additional information
Data on aquatic effects of 4-ADPA are available on three trophic levels (fish, daphnia and algae) for short-term toxicity and on two trophic levels (daphnia and algae) for long-term effect. The most sensitive acute toxicity is to aquatic invertebrates (Daphnia magna) with a 48h-EC50 of 0.29 mg/L. The most sensitive long-term study is also for aquatic invertebrates (Dapnia magna) with a 21d-EC50-reproduction of 0.1 mg/L and a NOEC-reproduction of 0.04 mg/L. For the assessment of microorganisms in biological treatment plants, an EC50 of 511 mg/l and an EC0 value of 31.25 mg/l to the growth inhibition of Pseudomonas putida were observed after 30 min exposure. Inhibition to nitrification was investigated by Chudoba 1986 with a 24-hour EC50 of 30 mg/l.
According to column 2 of REACH Annex IX, further long-term toxicity tests should be proposed by the registrant if the chemical safety assessment indicates the need to further investigate effects on aquatic organisms as indicated by a PEC/PNEC ratio > 1. Having a PEC/PNEC ratio <1 for all exposure scenarios, there is no need to perform a long-term assay as the risk towards aquatic organisms is sufficiently controlled based on the already available information.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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