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Diss Factsheets
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EC number: 251-013-5 | CAS number: 32360-05-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OSHA Toxicity Screening Test. Limited documentation of the study. No detailed description of the test substance available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Guideline:
- other: OSHA Toxicity Screening Test
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- other: single dose
- Limit test:
- yes
Test material
- Reference substance name:
- Dodecyl pentadecyl methacrylate
- IUPAC Name:
- Dodecyl pentadecyl methacrylate
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino rabbits
- Sex:
- male
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- undiluted
- Doses:
- Dosage: 5000 mg/kg
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 0, 7 and 14 days
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- In the observation period of 14 days, 1 of 6 experimental animals died.
- Clinical signs:
- other: Dodecyl pentadecyl methacrylate was severely irritating to the skin of the albino rabbit. Skin changes at 24 hours were characterized by pale red to red, well-defined erythema, moderate edema and second degree burns. Escharosis, wrinkling and fissuring we
- Gross pathology:
- Necropsy examination revealed hemorrhaged lungs in rabbit No. 2 and 3; and emaciation and depletion of body fat stores in rabbit No. 3, 4 and 6.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute dermal toxicity study with Dodecyl pentadecyl methacrylate with male albino rabbits, an LD50 > 5000 mg/kg was observed.
- Executive summary:
In an acute dermal OSHA toxicity screening test with Dodecyl pentadecyl methacrylate (purity: unknown), the test substance was administered undiluted with a dosage of 5000 mg/kg. b.w.
The determined LD50 was > 5000 mg/kg in male albino rabbits.
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