Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 251-013-5 | CAS number: 32360-05-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- There is one relevant, adequate and reliable study with structural analogue dodecyl methacrylate available (FHG, 1988) (Klimisch score = 1) The test was performed in accordance with generally accepted scientific standards and described in sufficient detail. Guideline study OECD 401, GLP.
This result is supported by three other acute oral toxicity studies with structuraly analogue long chain alkyl methacrylate esters (C12 -C22) with LD50 values above 5000 mg/kg. These results indicate a very low toxic potential of the long-chain alkyl methacrylate esters (C12 – C22).
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Inhalation is no relevant route of exposure and testing by inhalation is not appropriate. Exposure of humans via inhalation is unlikely taking into account the low vapour pressure and the low possibility of exposure to aerosols, particles or droplets of an inhalable size.
Furthermore no reliable data are available on long-chain methacrylate esters (C12 – C22) for the inhalation route. However, data are available on the structural analogues substances: methyl-, ethyl- and n-butyl methacrylate. The respective LC50 values are in a range between 5000 and 11000 ppm indicating low inhalation toxicity.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 000 mg/kg bw
- Quality of whole database:
- In a dermal acute toxicity study on isodecyl methacrylate (structurally related substance of tetradecyl methacrylate) with albino rabbits an
LD50 > 3000 mg/kg was determined. Reliable study according to generally accepted scientific standards and decribed in sufficient detail. This
experimentally observed result is supported by a dermal toxicity study with structural analogue dodecyl pentadecyl methacrylate where a LD50: > 5000 mg/kg, dermal, rabbit was observed (Rohm & Haas, 1975).
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
