Chlorotrimethylsilane

Endpoint summary

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via inhalation route

Dose descriptor:

NOAEC

2 666 mg/m³

Additional information

Adverse effects following large acute exposures can be assumed to be caused by the hydrolysis product HCl. However, this is not the case for smaller repeated exposures (including reproductive toxicity). Potential adverse effects following such exposures could be due to the other hydrolysis product,trimethylsilanol, and it is therefore important to consider these potential adverse effects. Since there are no data for chlorotrimethylsilane itself, data on the hydrolysis product, trimethylsilanol have been used. However, when considering results of trimethylsilanol for read-across, it is important to assume local effects (irritation/corrosion) in addition to the effects observed for trimethylsilanol.

Short description of key information:
There are no data on the possible adverse effects of chlorotrimethylsilane on fertility. Therefore results from a key inhalation OECD 422 study on the hydrolysis product, trimethylsilanol have been read-across to support this endpoint for chlorotrimethylsilane. In this study trimethylsilanol did not have adverse effects on fertility up to concentrations of 600 ppm (2666 mg/m3).

Effects on developmental toxicity

Description of key information

There are no data on the possible adverse effects of chlorotrimethylsilane on development of offspring. Therefore results from a key inhalation OECD 422 study on the hydrolysis product, trimethylsilanol have been read-across to support this endpoint for chlorotrimethylsilane. In this study trimethylsilanol did not have adverse effects on development up to concentrations of 600 ppm (2666 mg/m3). 

Effect on developmental toxicity: via inhalation route

Dose descriptor:

NOAEC

2 666 mg/m³

Additional information

It is considered appropriate to use this reliable result in support of the developmental toxicity endpoint for chlorotrimethylsilane as this substance is hydrolysed very rapidly in the presence of moisture to trimethylsilanol and hydrogen chloride.

Since chlorotrimethylsilane is hydrolysed to trimethylsilane and hydrogen chloride, additional local irritation can be expected due to the acidic nature of the HCl.

Toxicity to reproduction: other studies

Additional information

Adverse effects following large acute exposures can be assumed to be caused by the hydrolysis product HCl. However, this is not the case for smaller repeated exposures (including developmental toxicity). Potential adverse effects following such exposures could be due to the other hydrolysis product,trimethylsilanol, and it is therefore important to consider these potential adverse effects. Since there are no data for chlorotrimethylsilane itself, data on the hydrolysis product, trimethylsilanol have been used. However, when considering results of trimethylsilanol for read-across, it is important to assume local effects (irritation/corrosion) in addition to the effects observed for trimethylsilanol.

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