Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-900-5 | CAS number: 75-77-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Information is available from reliable studies for all the required in vitro endpoints. Where there was more than one result for an endpoint the most reliable study available was chosen as key study. Where there was more than one reliable study, the most recent study was selected. The results of all the studies were in agreement.
Short description of key information:
Gene mutation (Bacterial reverse mutation assay / Ames test):
negative with and without activation in all strains tested (similar to
OECD TG 471)
Cytogenicity in mammalian cells: negative in mouse lymphome L5178Y cells
(similar to OECD TG 473)
Mutagenicity in mammalian cells: negative in L5178Y mouse lymphoma cells
(similar to OECD TG 476)
In vivo:
Mammalian Bone Marrow Chromosome Aberration Test (ip study) in rat:
negative (similar to OECD TG 475)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The available information for the substance indicates that when tested in vitro, chlrotrimethylsilane (CAS number 75 -77 -4) did not induce mutations in bacterial or mammalian cells, nor chromosome aberrations in mammalian cells. In addition, the test substance did not induce mutations in yeast or sister chromatid exchanges in mammalian cells. An in vitro unscheduled DNA synthesis assay and an E. coli pol A assay also gave negative results. The conclusion reached from the in vitro results is confirmed by the negative result obtained when the analogous substance was tested in vivo in a rat bone marrow chromosomeaberration assay. Therefore it is considered that classification for mutagenicity is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
