Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Information retrieved from secondary literature without access to original literature reference.

Data source

Reference
Reference Type:
publication
Title:
ACETYLACETONE
Author:
HSDB
Year:
2009
Bibliographic source:
HAZARDOUS SUBSTANCES DATA BANK (HSDB) search

Materials and methods

Study type:
other: Summary
Endpoint addressed:
acute toxicity: oral
acute toxicity: inhalation
acute toxicity: dermal
skin irritation / corrosion
eye irritation
Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
not applicable

Method

Type of population:
not specified
Subjects:
no data
Ethical approval:
not specified
Route of exposure:
dermal
inhalation
oral
ocular
Reason of exposure:
other: unintentional, non-occupational and general
Exposure assessment:
not specified
Details on exposure:
no data
Examinations:
no data
Medical treatment:
no data

Results and discussion

Clinical signs:
2,4-Pentanedione was reported to be mildly irritating to skin and mucous membranes; vapour may cause unspecific effects such as dizziness, headache, nausea, vomiting and loss of consciousness
Results of examinations:
Exposure of humans towards 2,4-pentanedione vapour may cause unspecific effects such as dizziness, headache, nausea, vomiting and loss of consciousness. Skin irritation appears less hazardous. The acute oral toxicity is high. In humans the substance reveals moderate systemic ef-fects after inhalation.

Applicant's summary and conclusion

Conclusions:
Since this data are difficult to evaluate due to poor description of the results and the animal experiment show a weak if any local irritation after single application, which is more pronounced only after prolonged exposure.
Executive summary:

Regarding effects on humans only very little information is available. In the public literature it is described that exposure of humans towards 2,4-pentanedione vapour may cause unspecific effects such as dizziness, headache, nausea, vomiting and loss of consciousness.

Skin irritation appears less hazardous and effects are mild while eye burns similar to soap may result from a large application.

It has been reported that 2,4-pentanedione is appreciably more toxic by oral ingestion and vapor inhalation than either 1,2- or 1,4-diketones and saturated monoketones. The acute oral toxicity is high and internal consumption should be avoided. It is comparable in this respect to mesityl oxide. Breathing 2,4-pentanedione vapors may cause dizziness, headache, nausea, vomiting, and loss of consciousness. Skin irritation appears less hazardous. However, eye burns may result from a large application, similar to soap.

It is also reported that the material causes slight local irritant effects which are readily reversible and disappear after the end of exposure. In humans the substance reveals moderate systemic effects after inhalation which do not lead to death or permanent injury due to the low degree of severity. Acute local effects: 2,4-Pentanedione causes irritant effects which have been reported to be slight. Changes are readily reversible and disappear after end of exposure.

Acute systemic effects: After inhalation 2,4-pentanedione causes moderate effects and may involve both reversible and irreversible changes which are not strong enough to cause death or permanent injury. Since this data are difficult to evaluate due to poor description of the results and the animal experiment show a weak if any local irritation after single application, which is more pronounced only after prolonged exposure.