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Registration Dossier
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EC number: 204-634-0 | CAS number: 123-54-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information retrieved from secondary literature without access to original literature reference.
Data source
Reference
- Reference Type:
- publication
- Title:
- ACETYLACETONE
- Author:
- HSDB
- Year:
- 2 009
- Bibliographic source:
- HAZARDOUS SUBSTANCES DATA BANK (HSDB) search
Materials and methods
- Study type:
- other: Summary
- Endpoint addressed:
- acute toxicity: oral
- acute toxicity: inhalation
- acute toxicity: dermal
- skin irritation / corrosion
- eye irritation
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Pentane-2,4-dione
- EC Number:
- 204-634-0
- EC Name:
- Pentane-2,4-dione
- Cas Number:
- 123-54-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- pentane-2,4-dione
- Details on test material:
- not applicable
Constituent 1
Method
- Type of population:
- not specified
- Subjects:
- no data
- Ethical approval:
- not specified
- Route of exposure:
- dermal
- inhalation
- oral
- ocular
- Reason of exposure:
- other: unintentional, non-occupational and general
- Exposure assessment:
- not specified
- Details on exposure:
- no data
- Examinations:
- no data
- Medical treatment:
- no data
Results and discussion
- Clinical signs:
- 2,4-Pentanedione was reported to be mildly irritating to skin and mucous membranes; vapour may cause unspecific effects such as dizziness, headache, nausea, vomiting and loss of consciousness
- Results of examinations:
- Exposure of humans towards 2,4-pentanedione vapour may cause unspecific effects such as dizziness, headache, nausea, vomiting and loss of consciousness. Skin irritation appears less hazardous. The acute oral toxicity is high. In humans the substance reveals moderate systemic ef-fects after inhalation.
Applicant's summary and conclusion
- Conclusions:
- Since this data are difficult to evaluate due to poor description of the results and the animal experiment show a weak if any local irritation after single application, which is more pronounced only after prolonged exposure.
- Executive summary:
Regarding effects on humans only very little information is available. In the public literature it is described that exposure of humans towards 2,4-pentanedione vapour may cause unspecific effects such as dizziness, headache, nausea, vomiting and loss of consciousness.
Skin irritation appears less hazardous and effects are mild while eye burns similar to soap may result from a large application.It has been reported that 2,4-pentanedione is appreciably more toxic by oral ingestion and vapor inhalation than either 1,2- or 1,4-diketones and saturated monoketones. The acute oral toxicity is high and internal consumption should be avoided. It is comparable in this respect to mesityl oxide. Breathing 2,4-pentanedione vapors may cause dizziness, headache, nausea, vomiting, and loss of consciousness. Skin irritation appears less hazardous. However, eye burns may result from a large application, similar to soap.
It is also reported that the material causes slight local irritant effects which are readily reversible and disappear after the end of exposure. In humans the substance reveals moderate systemic effects after inhalation which do not lead to death or permanent injury due to the low degree of severity. Acute local effects: 2,4-Pentanedione causes irritant effects which have been reported to be slight. Changes are readily reversible and disappear after end of exposure.
Acute systemic effects: After inhalation 2,4-pentanedione causes moderate effects and may involve both reversible and irreversible changes which are not strong enough to cause death or permanent injury. Since this data are difficult to evaluate due to poor description of the results and the animal experiment show a weak if any local irritation after single application, which is more pronounced only after prolonged exposure.
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