Trizinc bis(orthophosphate)

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

Used in EU risk assessment for zinc oxide

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1982

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Zinc oxide

EC Number:

215-222-5

EC Name:

Zinc oxide

Cas Number:

1314-13-2

Molecular formula:

ZnO

IUPAC Name:

oxozinc

Details on test material:

Aerosol concentration was 5.7 mg/l and the particle size distribution had a mass median aerodynamic diameter of 4 m ± 2.9 (GSD)

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

no information available

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

nose/head only

Vehicle:

other: no data

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

ca. 4 h

Concentrations:

Aerosol concentration was 5.7 mg/l

No. of animals per sex per dose:

10 per sex

Control animals:

yes

Details on study design:

10 male and 10 female animals per group were exposed to zinc oxide aerosol (head and nose only) for 4 h. Aerosol concentration was 5.7 mg/l and the particle size distribution had a mass median aerodynamic diameter of 4 µm ± 2.9 (GSD). Only one concentration and a control group were tested. All animals survived up to day 14 post exposure.

Statistics:

no information

Results and discussion

Preliminary study:

no information

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

> 5 700 mg/m³ air

Exp. duration:

4 h

Mortality:

no mortality

Clinical signs:

other: only a dusty fur on the head, no adverse effects noted

Body weight:

no change in body weights observed

Gross pathology:

no adverse effects observed.

Other findings:

none observed

Any other information on results incl. tables

no information

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

LC50 4 hours >5.7 mg ZnO/l

Executive summary:

In an acute inhalation toxicity study, 10 male and 10 female animals per group were exposed to zinc oxide aerosol (head and nose only) for 4 h. Aerosol concentration was 5.7 mg/l and the particle size distribution had a mass median aerodynamic diameter of 4mm ± 2.9 (GSD). Only one concentration and a control group were tested. All animals survived up to day 14 post exposure. Apart from a dusty fur on the head the day after the exposure, no effects were seen. Body weights developed normally. At pathological examination all organs were normal. The LC₅₀was >5.7 mg/l.