Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-921-9 | CAS number: 13048-33-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- In principle, the methods described in the OECD Guideline 401 were used. Young adult laboratory rats were purchased from breeder. Several groups of 5 rats per sex and dose were treated simultaneously by gavage with preparations of the test substance in suitable vehicle. The concentrations of these preparations were used to achieve comparable volumes per kg body weight. Group-wise documentation of clinical signs was performed over the 14 day study period.
- GLP compliance:
- no
- Remarks:
- ; GLP was not compulsory at the time the study was conducted
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Hexamethylene diacrylate
- EC Number:
- 235-921-9
- EC Name:
- Hexamethylene diacrylate
- Cas Number:
- 13048-33-4
- Molecular formula:
- C12H18O4
- IUPAC Name:
- hexane-1,6-diyl bisacrylate
- Details on test material:
- - Name of test material (as cited in study report): 1,6-Hexanedioldiacrylate
- Physical state: liquid
- Analytical purity: > 90 % (techn.)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation:
mean body weight, males: 160 g in the 5000 mg/kg b.w. group
mean body weight, males: 140 g in the 2150 mg/kg b.w. group
mean body weight, females: 150 g in the 5000 mg/kg b.w. group
mean body weight, females: 160 g in the 2150 mg/kg b.w. group
- Fasting period before study:
15-20 hours
- Diet: Herilan MRH-Haltung; H. Eggersmann KG (ad libitum)
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50 % and 21.5 % for the 5000 and 2150 mg/kg b.w. dose level, respectively
- Amount of vehicle (if gavage): 10 ml/kg b.w. - Doses:
- 2150, 5000 mg/kg b.w.
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration:
14 days
- Frequency of observations and weighing:
Animals were observed and examined for clinical signs of toxicity during the first hour following application, after 4 and 5 hours and further on day 1, 2, 3, 6, 8, 9, 10 and 13 after dosing.
Mean body weights were determined for the following intervals of time: 2-4, 6-7 and 9-13 days of the study.
- Necropsy of survivors performed: yes
Deceased animals and those sacrificed at the end of the observation period were necropsied.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: One female in the 5000 mg/kg bw dose group died during the observation period, at day 7 after application
- Mortality:
- All males survived. One female in the 5000 mg/kg bw dose group died during the observation period, at day 7 after application.
- Clinical signs:
- other: No signs of toxicity were reported for the low dose group. For the high-dose group dyspnea (2 cases), aggressiveness (1 case), spastic walk (1 case) and bad general condition (1 case) were reported only at day 3 after application.
- Gross pathology:
- Necropsy of the female rat that died at day 5:
Acute congestion of the heart and dilatation of the atrium, substance-coloured content in gastrointestinal tract.
Necropsy of the survivors which were sacrificed after the end of the observation period of 14 days:
Findings were observed in the stomach and included thickening and plication of forestomach as well as its agglutination with liver, peritoneum, and spleen.
Any other information on results incl. tables
Table 1: Mean body weight of rats after oral application of Hexandiolacrylate, technical grade
|
Males |
Females |
||
Dose level [mg/kg bw] |
5000 |
2150 |
5000 |
2150 |
Day 2-4 |
170 |
171 |
146 |
182 |
Day 6-7 |
196 |
200 |
169 |
193 |
Day 9-13 |
239 |
212 |
192 |
193 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.