Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-907-1 | CAS number: 7778-53-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The test compound was administered by oral gavage to 10 rats and observed for adverse effects and drug induced toxicity for 14 days. All animals were autopsied and observed for gross pathological changes.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tripotassium orthophosphate
- EC Number:
- 231-907-1
- EC Name:
- Tripotassium orthophosphate
- Cas Number:
- 7778-53-2
- Molecular formula:
- H3O4P.3K
- IUPAC Name:
- tripotassium orthophosphate
- Test material form:
- other: substance is stated as being solid
- Details on test material:
- - Name of test material: MCTR-7-75
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Zartman Farms, Douglassville, Pa.
- Age at study initiation: no data
- Weight at study initiation: 200 - 300 g
- Fasting period before study: fasted for approximately 24 h prior to dose administration.
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: no data
- Amount of vehicle: no data
- Justification for choice of vehicle:no data
- Lot/batch no.: no data
- Purity: no data
MAXIMUM DOSE VOLUME APPLIED: no data
DOSAGE PREPARATION: no data
CLASS METHOD
- Rationale for the selection of the starting dose: no data - Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 10 males
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1, 3, 6 and 24 h and daily thereafter for a total of 14 days.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weights. - Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD100
- Effect level:
- 5 other: g/kg
- Based on:
- test mat.
- Mortality:
- See table
- Clinical signs:
- other: Loss of righting reflex, ptosis, respiratory depression and death occurred within the first 24 h post intubation.
- Gross pathology:
- Autopsies revealed no outstanding gross lesions.
- Other findings:
- No data
Any other information on results incl. tables
Table 1. Survival for the acute oral toxicity of MCTR-7 -75 in rats:
Dose (g/kg bw) |
No. per group |
Hour |
Day |
||||||||||||||||
1 |
3 |
6 |
24 |
48 |
72 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
Total |
||
5.0 |
10 |
10 |
5 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Table 2. Observations for the acute oral toxicity of MCTR-7 -75 in rats:
Dose (g/kg bw) |
Animal No. |
Hour |
|||||
1 |
3 |
6 |
24 |
48 |
72 |
||
5.0 |
1 |
Rr-R PT |
Rr-R PT |
Death |
|
|
|
2 |
Rr-R PT |
Death |
|
|
|
|
|
3 |
Rr-R PT |
Death |
|
|
|
|
|
4 |
Rr-R PT |
Death |
|
|
|
|
|
5 |
Rr-R PT |
Death |
|
|
|
|
|
6 |
Rr-R PT |
Death |
|
|
|
|
|
7 |
Rr-R PT |
Rr-R PT |
Rr-R PT |
Death |
|
|
|
8 |
Rr-R PT |
Rr-R PT |
Rr-R PT |
Death |
|
|
|
9 |
Rr-R PT |
Rr-R PT |
Death |
|
|
|
|
10 |
Rr-R PT |
Rr-R PT |
Rr-R PT |
Death |
|
|
PT - ptosis
R - respiratory depression
RR - loss of righting reflex
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The test substance when administered orally to Wistar-derived albino rats at a dose level of 5 mg/kg caused loss of rightling reflex, ptosis, respiratory depression and death. The LD50 is therefore considered to be <5g/kg bw.
This study does not meet the requirements for classification and labelling in accordance with Regulation (EC) No. 1272/2008, as only one dose level of 5 g/kg was tested (above for cut-off for classification under CLP). Therefore, for the purpose of the assessment of the acute oral toxicity of tripotassium orthophosphate this study has been disregarded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.