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Diss Factsheets
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EC number: 260-754-3 | CAS number: 57472-68-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- abraded skin
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Oxybis(methyl-2,1-ethanediyl) diacrylate
- EC Number:
- 260-754-3
- EC Name:
- Oxybis(methyl-2,1-ethanediyl) diacrylate
- Cas Number:
- 57472-68-1
- Molecular formula:
- C12H18O5
- IUPAC Name:
- oxydipropane-1,2-diyl bisacrylate
- Details on test material:
- - Name of test material (as cited in study report): A209415
- Physical state: liquid
- Analytical purity: no data
- Storage condition of test material: room temperature away from light
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Clerco Research Farms
- Age at study initiation: young adults
- Weight at study initiation: 2.75 to 3.10 kg
- Housing: individually housed in stainless steel wire-bottomed cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 26 days
ENVIRONMENTAL CONDITIONS
no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 240 cm2
- % coverage: 10 %
- Type of wrap if used: the test site was occluded with a layer of 4-ply gauze, two single layers thick. The trunk of the rabbit was wrapped with rubber
latex dental dam and the dental dam, taped at the edges with 1 inch Micropore, tape to form an airtight occlusive wrap.
REMOVAL OF TEST SUBSTANCE
after 24 hours the residual test material was wiped off
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1.88 ml/kg
- Constant volume or concentration used: yes - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female animals
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: frequently on the day of dosing and twice daily thereafter, weighing on the day before the study, day 0, day 6 and day 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no deaths
- Clinical signs:
- other: signs of systemic toxicity were observed on day 1 gradually decreasing in severity and incidence to day 6, when they were no longer present. These signs consisted of the following: eyes appear bluish, ears cool to touch, increased rate of respiration, hun
- Gross pathology:
- lungs spotted dark red in color in 1/5 female animals, lungs dark red in color in 4/5 male and 1/5 female animals. No significant other pathological
findings. - Other findings:
- Evaluation of local skin reactions revealed: erythema (10/10), edema (10/10), hemorrhage (9/10), eschar formation (9/10), fissuring (7/10), scattered raw areas (3/10), scaling (4/10), coriaceous (6/10), abraded lines well defined (2/10) and compound residue present (10/10)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.