Acetophenone

Endpoint summary

Additional information

Acetophenone is a colorless organic liquid that forms laminar crystals at low temperatures (mp: 20°C). It has a characteristic sweet orange blossom odor. It is found in nature in oil of castoreum, obtained from beavers, in oil of labdanum, recovered from plants, and in buds of balsam poplar. Acetophenone has a melting point of ca. 293.15K (range: 292.85-293.65K) and a boiling point of about 475.26K at normal pressure. The density and relative density of acetophenone at 20°C are reported to be about 1.03 g/cm³ (range: 1.0281 -1.03 g/cm³) and about 1.03 (range: 1.028 -1.03), respectively. The experimentally determined vapor pressure of acetophenone is reported to be 45 Pa (0.45 hPa) at 25°C. A vapor pressure of 0.353 hPa at 19.65°C was calculated using the following equation: Y=(A + B/T + C ln(T) + DT^E), Y in Pa, T in K and A=1.3287 x 10E2, B=-1.0385 x 10E4, C=-1.7284 x 10E1, D=1.4779 x 10E-2, and E=1. The error is stated to be 3%. Based on validated literature data and experimentally derived data obtained in studies conducted according or similar to OECD Guidelines, acetophenone has a log Kow in the range between 1.59 and 1.65 at room temperature. Based on the available experimental results and the information provided in peer-reviewed handbooks, acetophenone has a water solubility in the range between 6100 and 6300 mg/L at 25°C. Acetophenone is freely soluble in alcohol, chloroform, ether, fatty oils, and glycerol. The surface tension of pure acetophenone is reported to be 39.04 mN/m at 25°C. Based on the structure, surface active properties are not to be expected. The flash point determined via the the closed cup method is reported to be 105°C. The auto-ignition temperature of acetophenone is reported to be 535°C. According to REACH Regulation (Annex XI, 1.), a study does not need to be done if based on the available data the substance can be classified, labelled and/or the risk of the substance can be assessed. Acetophenone is a liquid at room temperature. For liquids the primary value for ease of ignition is the flash point. Moreover, the experience in the use and testing for other REACH endpoints showed that the substance does not ignite spontaneously in air or react violently with water and therefore testing according to EC Methods A.12 and A.13 is not scientifically necessary. According to REACH Regulation (Annex 7.11, column II), the study on explosiveness does not need to be done if the substance does not contain chemical groups indicating explosive properties. Acetophenone does not contain any functional groups indicating explosive properties. According to REACH Regulation (Annex VII, column II), the study on oxidising properties does not need to be done for substances which do not react exothermically with combustible substances based on their structure. Acetophenone does not contain any chemical groups indicating oxidising properties. Acetophenone has a dissociation constant of 21.55 at 25°C. A dynamic viscosity of 1.681 mPa x s at 25°C is reported for acetophenone.