Bis(2-ethylhexyl) maleate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

September 30 2010

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Expert Judgement

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Data source

Reference

Reference Type:

other: expert judgement

Title:

Unnamed

Year:

2010

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Risk Assessment

GLP compliance:

no

Test type:

other: expert judgement

Test material

Test material information

Constituent 1

Reference substance name:

Bis(2-ethylhexyl) maleate

EC Number:

205-524-5

EC Name:

Bis(2-ethylhexyl) maleate

Cas Number:

142-16-5

Molecular formula:

C20H36O4

IUPAC Name:

bis(2-ethylhexyl) but-2-enedioate

Constituent 2

Reference substance name:

Dioctyl maleate

EC Number:

220-835-6

EC Name:

Dioctyl maleate

Cas Number:

2915-53-9

Molecular formula:

C20H36O4

IUPAC Name:

dioctyl but-2-enedioate

Details on test material:

not applicable

Test animals

Species:

other: not applicable

Details on test animals or test system and environmental conditions:

not applicable

Administration / exposure

Route of administration:

other: expert judgement

Type of inhalation exposure:

other: expert judgement

Details on inhalation exposure:

expert judgement

Concentrations:

not applicable

No. of animals per sex per dose:

not applicable

Details on study design:

not applicable

Results and discussion

Effect levels

Dose descriptor:

discriminating conc.

Effect level:

2 500 mg/m³ air

Mortality:

not applicable

Clinical signs:

other: not applicable

Body weight:

not applicable

Gross pathology:

not applicable

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Based on physico-chemical properties, chemical characteristics, available toxicological profile and structural commonalities between bis(2-ethylhexyl) maleate and dibutyl maleate, and the lack of significant effects seen with this substance in the workplace, data for acute inhalation with dibutyl maleate is enough to fulfill this endpoint for bis(2-ethylhexyl) maleate and to avoid unnecessary testing on vertebrate animals (recital of 47 of REACH). The acute inhalation LC50 value of >5000 mg/m³ for dibutyl maleate can be used as surrogate for the purpose of this risk assessment.

Executive summary:

Diesters are generally produced from reaction of dicarboxylic acids and monoalcohols. Dibutyl maleate and bis(2-ethylhexyl) maleate are diester derivatives of the common diacid known as maleic acid (C4). The alcohol portion of these diesters falls in the C4-C8 carbon number range. Dibutyl maleate is derived from a linear alcohol (C4 = butanol) while bis(2-ethylhexyl) maleate is from a branched alcohol (not C8 = octonol but C6 = hexanol branched at C2 with C2 ethanol). According to the chemical structure bis(2-ethylhexyl) maleate is much more polar which would explain the lower water solubility and the different log Pow.

Data for inhalation exposure with bis(2-ethylhexyl) maleate in animals are not available. The relatively high boiling point (156°C @ 9 hPa) and very low vapor pressure (0.00022 Pa @ 20°C) of bis(2-ethylhexyl) maleate are indicative that the substance is essentially non volatile, and it is very likely that the substance will not reach the nasopharyngeal region or subsequently the tracheobronchial region via inhalation. Its very low hydrophilic character (log Pow 7.24) is not favorable for crossing the alveolar and capillary membranes and the relatively low water solubility of bis(2-ethylhexyl) maleate is not favorable for dissolution of the substance in the mucus lining of the respiratory tract. If bis(2-ethylhexyl) maleate is inhaled, none or very little significant absorption of the substance is to be expected. Therefore, bis(2-ethylhexyl) maleate does not present an inhalation hazard if exposure occurs. The acute inhalation LC50 value of dibutyl maleate (>5000 mg/m³) can be used as surrogate for the purpose of this risk assessment.