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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 403 (1981)
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Dastib 845
IUPAC Name:
Dastib 845
Details on test material:
Physical form of substance: S
Mass median aerodynamic diameter (for liq.+solid aerosol):
Produkt ist wachsartiges festes material: Mittlere
Teilchengrosse ist nicht definiert.

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
Acclimatization period: 5 days
temperature: 22±2°C
humidity: 60-70%
12 h light regime

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: Fur das Produkt wurde kein aerodynamischer Durchmesser benutzt, da es sich um einen wachsartigen Feststoff handelt. For the product was not used aerodynamic diameter, since it is a waxy solid.
Details on inhalation exposure:
Gesamter KÈrper
Duration of exposure for control / test groups: 7 h
Air-flow through the chember for control/ test groups: 11 L/min.
Temperature inside the chamber for control/test groups : 28 ± 2°C
Temperature of the water bath for control/test groups: 50 ±1°C
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
7 h
Concentrations:
The total amount of the Dsatib found has been determined after 7 hours as 22.0 mg in the first washing bottle and 1.1 mg in the second washing bottle. The total amount of Dastib 845 passed through the inhalation chamber during an inhalation experiment has been determined as 23.1 mg, when the total volume od 4.62 m3 of air having been passed. Concentration = 0.005 mg/L.
No. of animals per sex per dose:
5 males for control and a test groups
5 females for control and a test group
Control animals:
yes
Details on study design:
control group: 5 males + 5 females

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 0.005 mg/L air
Exp. duration:
7 h
Mortality:
Male: .005 mg/L; Number of animals: 5; Number of deaths: 0
Female: .005 mg/L; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Das Aussehen und Verhalten der behandelten Tiere wurde wahrend des 14-tagigen Observierungszeitraum nicht beeinflusst. Das Korpergewicht verandert sich nicht. The appearance and behavior of the treated animals was
Gross pathology:
Effects on organs: Es zeigten sich keine behandlungsbezogenen Auswirkungen in irgendeinem der Organe der Tiere, die der Prufsubstanz ausgesetzt wurden. Eine Abnahme der somatomotorischen Aktivitaten wurden sowohl in den Kontrollgruppen als auch den Versuchsgruppen festgestellt. Diese Observation bezog sich auf die gesenkte Temperatur in der Versuchskammer.
There were no treatment-related effects in any of the organs of the animals that were exposed by substance. A decrease in the somatomotor activities were both in control and the test groups noted. This observation related to the reduced temperature in the test chamber.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU