Registration Dossier

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.266 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
300
Modified dose descriptor starting point:
NOAEL
Acute/short term exposure
DNEL related information

Workers - Hazard for the eyes

Additional information - workers

From the 28-day sub-acute oral toxicity study a NOAEL of 40 mg/kgbw/day is established. This level is used to estimated the risk for adverse systemic health effects. Due to a nature of the substance 50% absorption for dermal route is assumed, then corrected dermal NOAEL results in 80 mg/kgbw/day. Alometric scaling factor:4; interspecies differences: 2,5; differences in exposure duration: 6; intraspecies differences(workers): 5;

General Population - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard via oral route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

Penetration of substance from the polymer matrix into the skin can be excluded on account of strong binding of the substance in the matrix.

The substance is not expected to pose the risk to the public at large via environment.