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Description of key information

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
LOAEL
1 mg/kg bw/day
Study duration:
chronic
Species:
dog

Additional information

Oral - The only effect that could be attributed to TNG in this study was a mild methemoglobinemia that was not accompanied by any of the sequelae of a severe methemoglobinemia such as Heinz bodies, elevated reticulocytes, and anemia. Except for the dogs receiving 25 mg TNG / kg / day, methemoglobin levels returned to zero after a thirty day recovery period.


Repeated dose toxicity: via oral route - systemic effects (target organ) cardiovascular / hematological: aorta

Justification for classification or non-classification

In accordance to the description in column 2 point 8.5.2 appendix VIII and results of measurements a conditions of work (see Exposure scenario for production of GTN and production of explosives) there doesn't exist vapors of GTN.