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Long-term toxicity to aquatic invertebrates

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According to Annex XI, Section 1.3 of REACH, results obtained from valid qualitative or quantitative structure-activity

relationship models ((Q)SARs) may indicate the presence or absence of a certain dangerous property. Results of (Q)SARs may be used instead of testing when the following conditions are met:

— results are derived from a (Q)SAR model whose scientific validity has been established,

— the substance falls within the applicability domain of the (Q)SAR model,

— results are adequate for the purpose of classification and labelling and/or risk assessment, and

— adequate and reliable documentation of the applied method is provided.

The long-term toxicity on aquatic invertebrates has been assessed using the OECD QSAR Toolbox v4.4. A 21-d NOEC for reproduction of Daphnia magna was derived using a trend analysis of the standardized workflow for ecotoxicological endpoints as provided by the Toolbox. The resulting 21-d NOEC was 27.5 mg/L. The Substance is within the applicability domain of the model. A robust study summary for this endpoint has been provided, which contains all relevant and required information. Therefore, the Registrant will not perform a study on the long-term toxicity to aquatic invertebrates.