Registration Dossier
Registration Dossier
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EC number: 213-030-6 | CAS number: 917-61-3
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Review data only.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inorganic substances containing I-IV group elements)
- Author:
- Filov V.A.
- Year:
- 1 988
- Bibliographic source:
- Chimia, 1988, page 351
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Public available literature. No guideline indicated. For details on method see materials and methods section.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Sodium cyanate
- EC Number:
- 213-030-6
- EC Name:
- Sodium cyanate
- Cas Number:
- 917-61-3
- Molecular formula:
- CNO.Na
- IUPAC Name:
- sodium cyanate
- Details on test material:
- no details given
Constituent 1
Test animals
- Species:
- monkey
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not indicated.
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Details on exposure:
- not indicated.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 60 days
- Frequency of treatment:
- not indicated.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
not indicated.
- No. of animals per sex per dose:
- not indicated.
- Control animals:
- not specified
- Details on study design:
- not indicated.
Examinations
- Observations and examinations performed and frequency:
- not indicated.
- Sacrifice and pathology:
- not indicated.
- Other examinations:
- not indicated.
- Statistics:
- not indicated.
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- effects observed, treatment-related
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- Spinal Cord - meningeal changes
Effect levels
- Key result
- Dose descriptor:
- other: TDLo - Lowest published toxic dose
- Effect level:
- 1 500 other: mg/kg/60 days
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Spinal Cord - meningeal changes equivalent to 25 mg/kg bw/day
Applicant's summary and conclusion
- Conclusions:
- The TDLo (lowest published toxic dose) = 1500 mg/kg/ 60 days equivalent to 25 mg/kg bw/day (intermittent).
- Executive summary:
In a subacute toxicity study sodium cyanate was administered to monkeys subcutaneous for 60 days.
Effects: Spinal Cord - meningeal changes
The TDLo (lowest published toxic dose) = 1500 mg/kg/ 60 days equivalent to 25 mg/kg bw/day (intermittent).
This subacute study in the rat is acceptable, as supporting study.
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