Registration Dossier
Registration Dossier
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EC number: 213-030-6 | CAS number: 917-61-3
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Review article only. Read across to sodium cyanate. For justification of read across see endpoint summary.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inorganic substances containing I-IV group elements)
- Author:
- Filov V.A.
- Year:
- 1 988
- Bibliographic source:
- Chimia, 1988, page 351
Materials and methods
- Study type:
- not specified
- Endpoint addressed:
- repeated dose toxicity: oral
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Public available literature. No guideline indicated. For details on method see materials and methods section.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium cyanate
- EC Number:
- 213-030-6
- EC Name:
- Sodium cyanate
- Cas Number:
- 917-61-3
- Molecular formula:
- CNO.Na
- IUPAC Name:
- sodium cyanate
Constituent 1
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
- Route of exposure:
- other: unreported, most probably oral
- Reason of exposure:
- other: no data, most probably intentional
- Exposure assessment:
- not specified
- Details on exposure:
- duration of exposure: 26 weeks
Results and discussion
- Clinical signs:
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified
TDLo - Lowest published toxic dose = 5475 mg/kg/ 26 weeks equivalent to 30 mg/kg bw/day (intermittent)
Applicant's summary and conclusion
- Conclusions:
- TDLo - Lowest published toxic dose (human) = 5475 mg/kg/26 weeks equivalent to 25 mg/kg bw/day (intermittent)
- Executive summary:
In a 26 weeks human study sodium cyanate was administered most probably oral.
Effects observed:
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
TDLo - Lowest published toxic dose = 5475 mg/kg/26 weeks equivalent to 25 mg/kg bw/day (intermittent)
This study in humans is acceptable as supporting study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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