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Diss Factsheets
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EC number: 201-070-7 | CAS number: 77-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- other: secondary source
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Evaluated as reliable by authoritative bodies, including the JECFA, EFSA, CSTEE, U.S. Environmental Protection Agency, Cosmetic Ingredient Review Panel, etc.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Science Assessment of ATBC and TEC
- Author:
- Boyle K
- Year:
- 2 004
- Bibliographic source:
- Memorandum from Kathryn Boyle, Inerts team to Dan Rosenblatt, Chief, Minor Use, Inerts and Emergency Response Branch.
- Report date:
- 2004
- Reference Type:
- secondary source
- Title:
- On the safety assessment of citric acid, inorganic citrate salts and alkyl citrate esters as used in cometics
- Author:
- Expert Panel, Cosmetic Ingredient Review
- Year:
- 2 012
- Bibliographic source:
- Cosmetic Ingredient Review, 1101 17th St. NW., Suite 412, Washington, DC 20036-4702
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Testing predates current accepted testing philosophies.
Test material
- Reference substance name:
- Triethyl citrate
- EC Number:
- 201-070-7
- EC Name:
- Triethyl citrate
- Cas Number:
- 77-93-0
- Molecular formula:
- C12H20O7
- IUPAC Name:
- triethyl citrate
- Test material form:
- liquid: viscous
- Details on test material:
- no data
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Concentration / amount:
- Induction: 2.5% in 0.01% Dobs/saline.
Induction-dermal: (occlusive patch application) with 100%.
Challenge (covered patch application) with 50% in absolute ethanol
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Concentration / amount:
- Induction: 2.5% in 0.01% Dobs/saline.
Induction-dermal: (occlusive patch application) with 100%.
Challenge (covered patch application) with 50% in absolute ethanol
- No. of animals per dose:
- 9 (one dose group)
- Details on study design:
- Nine guinea pigs according to the Magnusson-Kligman guinea pig maximization test method. Sensitization was induced by intradermal injections of both test substance and Freunds Adjuvant and the induction process supplemented seven days later by the test substance applied to the shoulder injection sites under occlusion. The animals were challenged by occluded patch 14 days later.
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- single dose
- No. with + reactions:
- 9
- Total no. in group:
- 9
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: single dose. No with. + reactions: 9.0. Total no. in groups: 9.0.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Triethyl citrate is a strong dermal sensitiser in guinea pigs, under the conditions of the Magnusson Kligman Maximization Test.
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