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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given (original publication not available). Peer-reviewed data source: OECD-SIDS

Data source

Referenceopen allclose all

Reference Type:
other company data
Title:
Unnamed
Year:
1973
Reference Type:
secondary source
Title:
p-Toluidine - CAS No: 106-49-0 - SIDS Initial Assessment Report.
Author:
OECD
Year:
2005
Bibliographic source:
UNEP Publications

Materials and methods

Principles of method if other than guideline:
In a subacute (28 days) feeding study, 10 male rats received 0, 165, 825 and 1650 ppm p-toluidine (corresponding to 0, 13.8, 66.8, 125.7 mg/kg bw/day), which was blended with basal diet freshly every week.

GLP compliance:
no
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
p-toluidine
EC Number:
203-403-1
EC Name:
p-toluidine
Cas Number:
106-49-0
Molecular formula:
C7H9N
IUPAC Name:
4-methylaniline
Constituent 2
Reference substance name:
p-chloraniline
IUPAC Name:
p-chloraniline
Details on test material:
- Name of test material (as cited in study report): p-toluidine
- Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
oral: feed
Details on exposure:

DIET PREPARATION
Dry material was blended with the basal diet to provide the desired levels; diets were prepared fresh weekly

Duration of treatment / exposure:
28 days
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 165, 825, 1650 ppm ( approx. 0, 13.8, 66.8, 125.7 mg/kg bw/day, calculated from food consumption)
Basis:
nominal in diet
Control animals:
yes, concurrent no treatment

Results and discussion

Observed effects

-No deaths or signs of intoxication were noted among any of the animals during the experimental period. -Terminal body weight: 1650 ppm significantly reduced whem compared to control: 292 g versus 343 g -Organ-body weight ratios (%) testes: there were no notable changes when compared to control: low-mid-high vers. contr. [%]: 0.88-0.88-1.1 vers. 0.92 -At autopsy, no significant gross pathologic lesions were found among any of the rats examined.

Applicant's summary and conclusion