Registration Dossier
Registration Dossier
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EC number: 231-588-9 | CAS number: 7646-78-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According OECD SIDS from 2006
Data source
Reference
- Reference Type:
- publication
- Title:
- Irritant and sensitizing potential of copper, mercury, and tin salts in experimental contact stomatitis of rat oral mucosa.
- Author:
- Larsson, A., B. Kinnby, R. Konsberg, M.J. Peszkowski, and G. Warfvinge
- Year:
- 1 990
- Bibliographic source:
- Contact Dermatitis. 23:146-153
Materials and methods
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Tin Tetrachloride [CAS No. 7646-78-8]; analytical grade (actual % purity and source not reported).
Constituent 1
In vivo test system
Test animals
- Details on test animals and environmental conditions:
- Animals: Sprague-Dawley rats, 2-3 months old
Vehicle: Alcohol or Alcohol + 0.25% Sodium Lauryl Sulfate (SLS)
Range of concentrations tested: 0.05-20%
Number of animals per test: 2-5
Food/water: standard diet + tap water, ad libitum
Results and discussion
Any other information on results incl. tables
The non-irritant level
was defined as the highest level that no tissue damage and/or
inflammatory reactions were clearly observed.
Non-irritant level (skin):
SnCl4: 5%
SnCl4 + 0.25% SLS: 5%
Non-irritant level (oral mucosa):
SnCl4: 0.05%
SnCl4 + 0.25% SLS: NA*
* - Not available; inconsistent results were obtained.
The test substance (SnCl4) was determined to be an irritant to oral
mucosa at levels >0.05%. The
combination SnCl4 + 0.25% SLS experiments resulted in no evidence of
lymphocytic infiltration. Results
of the combined SnCl4/SLS tests gave results similar to tests where
0.25% SLS was applied to the mucosa 1 minute prior to applying the SnCl4
solution.
In the sensitization tests, no reaction could be determined in animals
sensitized with 3% SnCl4/SLS, followed by oral elicitation with 0.05%
SnCl4.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Executive summary:
According to the above presented data form a publication there is no indication of an sensitizing potential.
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