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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

skin sensitisation, other
Type of information:
experimental study
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: According OECD SIDS from 2006

Data source

Reference Type:
Irritant and sensitizing potential of copper, mercury, and tin salts in experimental contact stomatitis of rat oral mucosa.
Larsson, A., B. Kinnby, R. Konsberg, M.J. Peszkowski, and G. Warfvinge
Bibliographic source:
Contact Dermatitis. 23:146-153

Materials and methods

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
Tin Tetrachloride [CAS No. 7646-78-8]; analytical grade (actual % purity and source not reported).

In vivo test system

Test animals

Details on test animals and environmental conditions:
Animals: Sprague-Dawley rats, 2-3 months old
Vehicle: Alcohol or Alcohol + 0.25% Sodium Lauryl Sulfate (SLS)
Range of concentrations tested: 0.05-20%
Number of animals per test: 2-5
Food/water: standard diet + tap water, ad libitum

Results and discussion

Any other information on results incl. tables

The non-irritant level was defined as the highest level that no tissue damage and/or inflammatory reactions were clearly observed.

Non-irritant level (skin):
SnCl4: 5%
SnCl4 + 0.25% SLS: 5%

Non-irritant level (oral mucosa):
SnCl4: 0.05%
SnCl4 + 0.25% SLS: NA*
* - Not available; inconsistent results were obtained.

The test substance (SnCl4) was determined to be an irritant to oral mucosa at levels >0.05%.
 The combination SnCl4 + 0.25% SLS experiments resulted in no evidence of lymphocytic infiltration. Results of the combined SnCl4/SLS tests gave results similar to tests where 0.25% SLS was applied to the mucosa 1 minute prior to applying the SnCl4 solution.

In the sensitization tests, no reaction could be determined in animals sensitized with 3% SnCl4/SLS, followed by oral elicitation with 0.05% SnCl4.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Migrated information
Executive summary:

According to the above presented data form a publication there is no indication of an sensitizing potential.