Registration Dossier
Registration Dossier
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EC number: 231-588-9 | CAS number: 7646-78-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No information whether study was conducted in accordance with GLP. Test performed with male animals only. Airflow rates through the inhala-tion equipment not reported. No necropsy or histopathological findings reported.
Data source
Reference
- Reference Type:
- other: OECD SIDS Dossier
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test material
- Reference substance name:
- Tin tetrachloride
- EC Number:
- 231-588-9
- EC Name:
- Tin tetrachloride
- Cas Number:
- 7646-78-8
- Molecular formula:
- Cl4Sn
- IUPAC Name:
- tin tetrachloride
- Test material form:
- liquid
- Details on test material:
- Tin Tetrachloride [CAS No. 7646-78-8]; >99% purity, source: Aldrich Chemical Co.
Constituent 1
Results and discussion
Any other information on results incl. tables
Mortality (number of
animals dead/total number tested), by mean dose level:
0.29 mg/l: 0/10 animals
0.67 mg/l: 3/10 animals (all deaths during exposure)
0.97 mg/l: 4/10 animals (2 deaths during exposure; 1 @ 24 h; 1 @ 6 d)
1.01 mg/l: 1/10 animals (death during exposure)
1.37 mg/l: 3/10 animals (all deaths during exposure)
1.77 mg/l: 7/10 animals (5 deaths during exposure; 1 overnight; 1 not
reported)
3.08 mg/l: 10/10 animals (8 deaths during exposure; 1 overnight; 1 @ 48
h)
Test substance vapors formed a white cloud upon contact with the
humidified air. Clinical
signs observed during exposure included labored respiration, gasping,
clear nasal and oral discharge, red ocular discharge, reduced response
to sound, and wet fur. Post-exposure,
surviving animals exhibited mild-to-moderate initial weight loss,
followed by normal weight gain over the 2 week observation period. One
animal from the 1.77 mg/l exposure group exhibited lung noise over the
entire observation period.
The acute inhalation LC50 of tin tetrachloride (95% confidence limits)
was calculated to be 1.35 (1.08-1.77) mg/l.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Executive summary:
see endpoint summary
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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