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EC number: 213-911-5 | CAS number: 1066-33-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Density
- Particle size distribution (Granulometry)
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- Endpoint summary
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- Environmental data
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
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- Exposure related observations in humans
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- Additional toxicological data

Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- The effects of administrations of HCl, NH4CI and NH4HCO3 on the excretion of urea and ammonium in man
- Author:
- Fine A et al.
- Year:
- 1 977
- Bibliographic source:
- European Journal of Clinical investigation (1977) 7, 587-589
Materials and methods
- Type of study / information:
- Study on effects of oral HCl, NH4CI and NH4HCO3 on urinary nitrogen excretion in man.
- Endpoint addressed:
- basic toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Ammonium hydrogencarbonate
- EC Number:
- 213-911-5
- EC Name:
- Ammonium hydrogencarbonate
- Cas Number:
- 1066-33-7
- Molecular formula:
- CH2O3.H3N
- IUPAC Name:
- ammonium hydrogen carbonate
Constituent 1
Method
- Exposure assessment:
- measured
- Details on exposure:
- TYPE OF EXPOSURE MEASUREMENT: Biomonitoring (urine)
EXPOSURE LEVELS: 200 mmol divided into four aliquots were ingested daily on three separate study periods and there was a control period
EXPOSURE PERIOD: four 4 day periods, randomized, and at 2 week intervals
POSTEXPOSURE PERIOD: 24 h
DIET: Protein intake 1 g/24 h/kg, as milk, was constant throughout and 3 litres fluid ingested per day
MEASUREMENT:
Blood and urinary urea, urinary NH4, plasma glutamine
Results and discussion
- Results:
- In man, HCI acidosis reduces blood and urinary urea with a concomitant rise in ammonium (NH4+) excretion. Significantly less urea is excreted following NH4Cl administration than following equimolar ingestion of NH4HCO3. The results of these alterations in nitrogen excretion are interpreted in terms of bicarbonate utilization and production.
Any other information on results incl. tables
Alterations in urea and NH4+ production following the daily administration of 200 mmol HCl, NH4Cl and NH4HCO3, as compared to a control period in four normal subjects. Figures refer to mean ± S.E.M. of values obtained during the last day of each period. Individual values are given where relevant:
Control | NH4HCO3 | ||||||||
Day 1 | Day 2 | Day 3 | Day 4 | Day 1 | Day 2 | Day 3 | Day 4 | ||
Plasma CO2 mmol/l) | 26 ± 0.6 | 26 ± 0.8* | |||||||
Plasma glutamine (mmol/l) | 0.583 ± 0.037 | 0.528 ± 0.062 | |||||||
Blood urea (mmol/l) | 5.93 ± 0.45 | 5.68 ± 0.4 | |||||||
Subject | 1 | 7.13 | 6.84 | ||||||
2 | 6.06 | 5.92 | |||||||
3 | 5.55 | 5.22 | |||||||
4 | 5 | 4.84 | |||||||
Urine urea (mmol/24 h) | 351 ± 9 | 477 ± 22# | |||||||
Subject | 1 | 382 | 361 | 373 | 366 | 418 | 432 | 422 | 427 |
2 | 361 | 340 | 320 | 347 | 427 | 457 | 462 | 472 | |
3 | 305 | 299 | 314 | 326 | 427 | 447 | 445 | 477 | |
4 | 346 | 327 | 348 | 364 | 546 | 517 | 522 | 530 | |
Urine NH4+ (mmol/24 h) | 33 ± 3 | 39 ± 4# | |||||||
Subject | 1 | 32 | 37 | 34 | 34 | 38 | 36 | 37 | 37 |
2 | 44 | 47 | 36 | 40 | 45 | 54 | 48 | 52 | |
3 | 32 | 31 | 33 | 35 | 35 | 39 | 30 | 37 | |
4 | 36 | 34 | 28 | 24 | 30 | 30 | 29 | 32 | |
Urine N (NH4+ urea N) | 734 ± 17 | 990 ± 43* | |||||||
Subject | 1 | 800 | 759 | 780 | 766 | 874 | 900 | 881 | 881 |
2 | 766 | 727 | 676 | 734 | 899 | 968 | 972 | 996 | |
3 | 642 | 629 | 661 | 687 | 889 | 933 | 920 | 991 | |
4 | 728 | 688 | 724 | 752 | 1122 | 1064 | 1073 | 1092 |
* Significantly different from controls (P < 0.025)
# Significantly different from NH4Cl (P < 0.005)
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